Oliver Smithies

University of North Carolina at Chapel Hill — United States

Medicine · Health Sciences

108h-index65.3kcitations405works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Renin-Angiotensin System Studies(69), Hormonal Regulation and Hypertension(66), CRISPR and Genetic Engineering(38), Receptor Mechanisms and Signaling(29), Pluripotent Stem Cells Research(25)

Publications403 total

Proximal aortic aneurysms in mice underexpressing transforming growth factor-β1
The Journal of Physiological Sciences·2025Open Access
Importance of quantitative genetic variations in the etiology of hypertension
UNC Libraries·2021Open Access
Altering the Expression in Mice of Genes by Modifying Their 3′ Regions
UNC Libraries·2021Open Access
Altering mice by homologous recombination using embryonic stem cells
UNC Libraries·2021Open Access
Apop-1, a Novel Protein Inducing Cyclophilin D-dependent but Bax/Bak-related Channel-independent Apoptosis
UNC Libraries·2021· 1 citedOpen Access
Receptor Activity-modifying Proteins 2 and 3 Have Distinct Physiological Functions from Embryogenesis to Old Age
UNC Libraries·2021Open Access
The Influence of Chromosomal Location on the Expression of Two Transgenes in Mice
UNC Libraries·2021· 1 citedOpen Access
Homeostasis in Mice with Genetically Decreased Angiotensinogen Is Primarily by an Increased Number of Renin-producing Cells
UNC Libraries·2021Open Access
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
UNC Libraries·2021Open Access
Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO)
UNC Libraries·2021· 5 citedOpen Access
Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca2+ release channel
UNC Libraries·2021· 4 citedOpen Access
Renin Cells Are Precursors for Multiple Cell Types that Switch to the Renin Phenotype When Homeostasis Is Threatened
UNC Libraries·2021· 1 citedOpen Access
Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition
UNC Libraries·2021Open Access
Postnatal development and progression of renal dysplasia in cyclooxygenase-2 null mice
UNC Libraries·2021Open Access
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
UNC Libraries·2021Open Access
Cyanocobalamin prevents cardiomyopathy in type 1 diabetes by modulating oxidative stress and DNMT-SOCS1/3-IGF-1 signaling
Communications Biology·2021· 17 citedOpen Access
Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice
UNC Libraries·2020Open Access
A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy
UNC Libraries·2020· 4 citedOpen Access
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade
UNC Libraries·2020Open Access
The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension
UNC Libraries·2020· 1 citedOpen Access
page 1 of 21Next →

Frequent Co-authors

John H. Krege(7), Nobuyo Maeda(7), Thomas M. Coffman(7), Jeffrey B. Hodgin(6), John R. Hagaman(6), Kenneth S. Korach(4), Joel F. Mahler(4), Robert Langenbach(4), Scott G. Morham(4), J. Charles Jennette(4), Hyung‐Suk Kim(4), John F. Couse(3), Jan-Ακε Gustafsson(3), Howard F. Tiano(3), Kimberly D. Kluckman(3), Ann E. Blechl(3), Beverly H. Koller(3), Edward G. Shesely(3), Susan B. Gurley(3), Nobuo Maeda(3)