John T. Santini

University of Melbourne — Australia

Engineering · Physical Sciences

14h-index2.7kcitations30works4.02yr avg
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Research Topics

Microfluidic and Capillary Electrophoresis Applications(10), Nanoplatforms for cancer theranostics(10), Cancer Research and Treatments(8), 3D Printing in Biomedical Research(6), Innovative Microfluidic and Catalytic Techniques Innovation(5)

Publications30 total

Phase 2 Dose-Ranging Trial of VGT-309 for Molecular Imaging of Cancer during Pulmonary Resection
European Journal of Cardio-Thoracic Surgery·2025Open Access
Phase 2 Clinical Trial of VGT-309 for Intraoperative Molecular Imaging During Pulmonary Resection
The Annals of Thoracic Surgery·2024· 8 citedOpen Access
Cathepsin detection to identify malignant cells during robotic pulmonary resection
Translational Lung Cancer Research·2023· 3 citedOpen Access
MA11.06 Results from a Phase II trial of a Tumor-Activated Fluorescent Molecule for the Intra-Operative Identification of Lung Cancer
Journal of Thoracic Oncology·2023· 1 citedOpen Access
Supplementary Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
2023Open Access
Supplementary Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
2023Open Access
Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
2023Open Access
Data from A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
2023Open Access
Preclinical evaluation of a novel cathepsin-activated fluorescent probe VGT-309 for identification of ovarian cancer in a mouse model (248)
Gynecologic Oncology·2022· 2 cited
A Cathepsin-Targeted Quenched Activity–Based Probe Facilitates Enhanced Detection of Human Tumors during Resection
Clinical Cancer Research·2022· 42 citedOpen Access
Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model
EJNMMI Research·2020· 44 citedOpen Access
An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors
Science Translational Medicine·2015· 186 citedOpen Access
Single compartment drug delivery
Journal of Controlled Release·2014· 53 citedOpen Access
Single compartment drug delivery
DSpace@MIT (Massachusetts Institute of Technology)·2014Open Access
Abstract LB-86: Preliminary results from an ongoing phase I trial of RRx-001, a tumor selective cytotoxic agent.
Cancer Research·2013· 1 cited
Reservoir-based drug delivery systems utilizing microtechnology
Advanced Drug Delivery Reviews·2012· 237 citedOpen Access
First-in-Human Testing of a Wirelessly Controlled Drug Delivery Microchip
Science Translational Medicine·2012· 423 cited
Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device
Nature Biotechnology·2006· 215 cited
Electrothermally activated microchips for implantable drug delivery and biosensing
Journal of Controlled Release·2005· 147 cited
Implantable microchips for controlled drug delivery
2005· 11 cited
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Frequent Co-authors

Michael J. Cima(11), Róbert Langer(11), Eric S. Bensen(11), Gregory T. Kennedy(7), Feredun Azari(7), Michael Egan(7), Gavin Wright(7), Sunil Singhal(7), Amy C. Richards(6), Rebecca A. Scheidt(6), Matthew Bogyo(6), David E. Holt(5), Elizabeth Bernstein(5), Bilal Nadeem(5), Ashley Chang(5), Neil T. Sullivan(5), Alix Segil(5), Charuhas Desphande(5), John C. Kucharczuk(5), Edward J. Delikatny(5)