Brian M. McKeever

University of Sydney — Australia

Materials Science · Physical Sciences

30h-index4.0kcitations78works0.02yr avg
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Research Topics

Enzyme Structure and Function(9), Hormonal Regulation and Hypertension(9), Receptor Mechanisms and Signaling(8), HIV/AIDS drug development and treatment(7), Peroxisome Proliferator-Activated Receptors(7)

Publications78 total

Suspect ‘baggage canine heartworm’ case: canine heartworm disease in a dog from Sydney, New South Wales
Australian Veterinary Journal·2021· 4 cited
A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia
Cancer Cell·2019· 425 citedOpen Access
Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor
Bioorganic & Medicinal Chemistry·2017· 16 citedOpen Access
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core
Bioorganic & Medicinal Chemistry Letters·2016· 10 citedOpen Access
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist
Journal of Medicinal Chemistry·2016· 32 citedOpen Access
Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists
Bioorganic & Medicinal Chemistry·2016· 27 citedOpen Access
Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease
Journal of Medicinal Chemistry·2013· 132 citedOpen Access
New Renin Inhibitor VTP-27999 Alters Renin Immunoreactivity and Does Not Unfold Prorenin
Hypertension·2013· 16 citedOpen Access
Regulation of Sphingomyelin Phosphodiesterase Acid-Like 3A Gene (SMPDL3A) by Liver X Receptors
Molecular Pharmacology·2012· 20 cited
Benzimidazolones: A New Class of Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) Modulators
Journal of Medicinal Chemistry·2011· 56 citedOpen Access
Structure of PPARgamma ligand binding domain in complex with (R)-5-(3-((3-(6-methoxybenzo[d]isoxazol-3-yl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)methyl)phenyl)-5-methyloxazolidine-2,4-dione
2011
Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility
ACS Medicinal Chemistry Letters·2011· 38 citedOpen Access
Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1
Journal of Medicinal Chemistry·2011· 40 citedOpen Access
Biphenyl/diphenyl ether renin inhibitors: Filling the S1 pocket of renin via the S3 pocket
Bioorganic & Medicinal Chemistry Letters·2011· 8 citedOpen Access
Clinically Useful Alkyl Amine Renin Inhibitors
2010
Alkyl Amine Renin Inhibitors: Filling S1 from S3
2010
World's oldest donor‐recipient solid organ transplantation?
Dialysis & Transplantation·2010· 2 citedOpen Access
Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1
Bioorganic & Medicinal Chemistry Letters·2010· 12 citedOpen Access
Spirocyclic ureas: Orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design
Bioorganic & Medicinal Chemistry Letters·2010· 25 citedOpen Access
Optimization of orally bioavailable alkyl amine renin inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 18 citedOpen Access
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Frequent Co-authors

Gerard M. McGeehan(12), Suresh B. Singh(11), Yuri Bukhtiyarov(11), David A. Claremon(10), Colin M. Tice(9), Wei Zhao(9), Joan Guo(9), Fausto Ramírez(8), Manuel A. Navia(7), James P. Springer(7), Raghupathy Sarma(7), Yi Zhao(7), James F. Marecek(7), Zhenrong Xu(6), Salvacion Cacatian(6), Paula M. Krosky(6), Richard K. Harrison(6), Reshma Panemangalore(6), Linghang Zhuang(6), Paula M.D. Fitzgerald(5)