Elisabeth M. Perchellet

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index2.1kcitations82works0.02yr avg
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Research Topics

Cancer therapeutics and mechanisms(19), Bioactive Compounds and Antitumor Agents(19), Polyamine Metabolism and Applications(11), Synthesis and biological activity(7), Synthetic Organic Chemistry Methods(7)

Publications82 total

Mechanisms by which synthetic 6,7-annulated-4-substituted indole compounds with anti-proliferative activity disrupt mitosis and block cytokinesis in human HL-60 tumor cells in vitro.
PubMed·2014· 4 cited
Antitumor effects of synthetic 6,7-annulated-4-substituted indole compounds in L1210 leukemic cells in vitro.
PubMed·2012· 5 cited
Bioactivity of synthetic 2-halo-3-aryl-4(3H)-quinazoliniminium halides in L1210 leukemia and SK-BR-3 mammary tumor cells in vitro.
PubMed·2011· 11 cited
ChemInform Abstract: Synthesis and Antiproliferative Evaluation of 5‐oxo and 5‐thio Derivatives of 1,4‐Diaryl Tetrazoles.
ChemInform·2010
Structure-Activity Relationship Studies of a Novel CXCR4 Chemokine Antagonist Reveal Unique Activity Profile
2010
Synthesis and antiproliferative evaluation of 5-oxo and 5-thio derivatives of 1,4-diaryl tetrazoles
Bioorganic & Medicinal Chemistry Letters·2010· 72 cited
Synthesis, Molecular Targets, and Antitumor Activities of Substituted Tetrahydro-1- Oxopyrano[4,3-b][1]Benzopyrans and Nanogels for Drug Delivery
Anti-Cancer Agents in Medicinal Chemistry·2009· 6 cited
Erratum
Digestion·2009Open Access
ChemInform Abstract: Synthesis of a Natural Product‐Inspired Eight‐Membered Ring Lactam Library via Ring‐Closing Metathesis.
ChemInform·2008
Design and Synthesis of Medium-Ring Lactam Libraries Inspired by Octalactin A. A Convergent−Divergent Approach
Journal of Combinatorial Chemistry·2008· 16 citedOpen Access
Synthesis of a natural product-inspired eight-membered ring lactam library via ring-closing metathesis
Bioorganic & Medicinal Chemistry Letters·2008· 26 citedOpen Access
Total syntheses of (±)-ovalicin, C4(S∗)-isomer, and its C5-analogs and anti-trypanosomal activities
Bioorganic & Medicinal Chemistry·2008· 13 citedOpen Access
Antitumor triptycene analogs directly interact with isolated mitochondria to rapidly trigger markers of permeability transition.
PubMed·2007· 13 cited
Novel substituted 1,4-anthracenediones with antitumor activity directly induce permeability transition in isolated mitochondria
International Journal of Oncology·2007· 7 citedOpen Access
Antiproliferative and proapoptotic activities of pyranoxanthenones, pyranothioxanthenones and their pyrazole-fused derivatives in HL-60 cells.
PubMed·2006· 21 cited
Syntheses, Molecular Targets and Antitumor Activities of Novel Triptycene Bisquinones and 1,4-Anthracenedione Analogs
Anti-Cancer Agents in Medicinal Chemistry·2006· 17 cited
Antitumor triptycene analogs induce a rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria
International Journal of Oncology·2006· 13 cited
Rapid collapse of mitochondrial transmembrane potential in HL-60 cells and isolated mitochondria treated with anti-tumor 1,4-anthracenediones
Anti-Cancer Drugs·2005· 24 cited
Imidazole-4,5-dicarboxamide Derivatives with Antiproliferative Activity against HL-60 Cells
Journal of Medicinal Chemistry·2005· 37 cited
Synthesis and in vitro Antitumor Activity of Substituted Anthracene‐1,4‐diones.
ChemInform·2005· 3 cited
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Frequent Co-authors

Jean‐Pierre Perchellet(38), Duy H. Hua(19), Jean‐Pierre H. Perchellet(9), Hala U. Gali(8), Kaiyan Lou(8), Masafumi Tamura(6), Nancy L. Abney(5), Srinivas K. Battina(5), Bonnie J Sperfslage(5), James B. Ladesich(4), Peter K. Chiang(4), Xiaodong Huang(4), Huiping Zhao(4), Darren S. Klish(3), Keith R. Buszek(3), Yang Wang(3), Jan M. Johnson(2), Ryan M. Thomas(2), Hong‐Sig Sin(2), Xiaohu Gao(2)