Alejandra Tomás

Imperial College London — United Kingdom

Medicine · Health Sciences

35h-index4.0kcitations155works2.52yr avg
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Research Topics

Pancreatic function and diabetes(96), Diabetes Treatment and Management(77), Receptor Mechanisms and Signaling(67), Neuropeptides and Animal Physiology(24), Metabolism, Diabetes, and Cancer(23)

Publications154 total

Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation
Molecular Metabolism·2025· 1 citedOpen Access
GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and function
Nature Communications·2025· 4 citedOpen Access
Glucagon-like peptide-1 receptor C-terminal tail phosphorylation determines signalling responses from pancreatic β-cells
2025Open Access
Editorial: The impact of GIP/GIPR on metabolic diseases: how the field is evolving
Frontiers in Endocrinology·2025Open Access
Binding kinetics, bias, receptor internalization and effects on insulin secretion in vitro and in vivo of a novel <scp>GLP</scp> ‐ <scp>1R</scp> / <scp>GIPR</scp> dual agonist, <scp>HISHS</scp> ‐2001
Diabetes Obesity and Metabolism·2025· 1 citedOpen Access
Glycaemic and bodyweight effects of <i>GIPR</i> coding variation reflect differences in both surface expression and intrinsic functional impairment
2025Open Access
Author response: Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells
2025Open Access
Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells
eLife·2025· 7 citedOpen Access
Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells
2025Open Access
Author response: Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells
2025Open Access
Oppositely biased glucagon‐like peptide‐1 receptor agonism does not differentially affect lipid metabolism in <scp>APOE</scp> *3‐Leiden CETP mice
Diabetes Obesity and Metabolism·2025Open Access
Author response for "Oppositely biased glucagon‐like peptide‐1 receptor agonism does not differentially affect lipid metabolism in &lt;scp&gt;APOE&lt;/scp&gt;*3‐Leiden CETP mice"
2025
Author response for "Oppositely biased glucagon‐like peptide‐1 receptor agonism does not differentially affect lipid metabolism in &lt;scp&gt;APOE&lt;/scp&gt;*3‐Leiden CETP mice"
2025
The physiological impact of an N‐terminal Halo‐tag on glucose‐dependent insulinotropic polypeptide receptor function in mice
Diabetes Obesity and Metabolism·2025Open Access
Binding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion <i>in vitro</i> and <i>in vivo</i> of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001
2025· 2 citedOpen Access
Author response for "The physiological impact of an N‐terminal Halo‐tag on glucose‐dependent insulinotropic polypeptide receptor function in mice"
2025
Human class B1 GPCR modulation by plasma membrane lipids
2024· 2 citedOpen Access
The physiological impact of an N-terminal Halo-tag on GIPR function in mice
2024Open Access
<i>In vivo</i> functional profiling and structural characterisation of the human <i>Glp1r</i> A316T variant
2024· 1 citedOpen Access
Author response: Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells
2024Open Access
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Frequent Co-authors

Ben Jones(26), Guy A. Rutter(17), Stephen R. Bloom(13), David J. Hodson(12), Philippe A. Halban(11), Johannes Broichhagen(10), Stavroula Bitsi(9), Ivan R. Corrêa(7), Tricia Tan(7), Philip Pickford(6), Teresa Buenaventura(5), Pauline Chabosseau(5), Maria Lucey(5), Shiqian Chen(5), Victoria Salem(5), Yusman Manchanda(5), Asuka Inoue(4), Jeffrey E. Pessin(4), Julia Ast(4), Zijian Fang(4)