Michael J. Lenardo

National Institutes of Health — United States

Immunology and Microbiology · Life Sciences

106h-index53.4kcitations831works6.02yr avg
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Research Topics

Immune Cell Function and Interaction(116), Immunodeficiency and Autoimmune Disorders(68), Cell death mechanisms and regulation(62), T-cell and B-cell Immunology(61), NF-κB Signaling Pathways(54)

Publications827 total

CARD11 signaling regulates CD8+ T cell tumoricidal function
Nature Immunology·2025· 6 cited
A plain language summary of a study looking at the effects of pozelimab in children with CHAPLE disease
Future Rare Diseases·2025
The primate-specific Nedd4-1(NE) localizes to late endosomes in response to amino acids to suppress autophagy
Nature Communications·2025· 1 citedOpen Access
The Canadian collaborative project on genetic susceptibility to multiple sclerosis cohort population structure and disease etiology
Frontiers in Neurology·2025· 1 citedOpen Access
pH-dependent dissociation from CTLA-4 in early endosomes improves both safety and antitumor activity of anti-CTLA-4 antibodies
Proceedings of the National Academy of Sciences·2025· 2 citedOpen Access
The patient experience of CHAPLE disease: results from interviews conducted as part of a clinical trial for an ultra-rare condition
Orphanet Journal of Rare Diseases·2025· 1 citedOpen Access
AMBRA1 controls the translation of immune-specific genes in T lymphocytes
Proceedings of the National Academy of Sciences·2024· 5 citedOpen Access
Pozelimab for CHAPLE disease: results from in-trial interviews and clinical outcome assessments
Orphanet Journal of Rare Diseases·2024· 4 citedOpen Access
The Canadian Collaborative Project on Genetic Susceptibility to Multiple Sclerosis cohort population structure and disease etiology
2024Open Access
The prevalence and topography of spinal cord demyelination in multiple sclerosis: a retrospective study
Acta Neuropathologica·2024· 10 citedOpen Access
Author Correction: GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway
Nature Immunology·2024Open Access
Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study
The Lancet·2024· 25 citedOpen Access
GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway
Nature Immunology·2024· 10 citedOpen Access
Adult-onset neurodegeneration in XMEN disease
Journal of Neuroimmunology·2023· 3 citedOpen Access
Interim analysis: Open-label extension study of leniolisib for patients with APDS
Journal of Allergy and Clinical Immunology·2023· 30 citedOpen Access
Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards
Nature Reviews Gastroenterology & Hepatology·2023· 19 citedOpen Access
25 A phase 2/3 study evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE disease)
Immunobiology·2023· 2 cited
Protein-Losing Enteropathy
New England Journal of Medicine·2023· 58 cited
GIMAP5 deficiency reveals a human cellular longevity assurance pathway
The Journal of Immunology·2023Open Access
AMBRA1 control immune-specific gene expression in T lymphocytes
The Journal of Immunology·2023· 1 citedOpen Access
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Frequent Co-authors

Lixin Zheng(17), Helen C. Su(8), Richard M. Siegel(8), V. Koneti Rao(6), Stephen E. Straus(5), Janet K. Dale(5), Francis Ka-Ming Chan(5), Jin Wang(5), Hyung J. Chun(5), Gülbû Uzel(5), Helen Matthews(5), C. Lucas(5), David Baltimore(4), Li Yu(4), Fengyi Wan(4), Eric H. Baehrecke(4), Jennifer M. Puck(4), João Bosco Oliveira(4), Jeffrey I. Cohen(4), Hye Sun Kuehn(3)