Dylan G. Ryan

University of Cambridge — United Kingdom

Immunology and Microbiology · Life Sciences

21h-index6.6kcitations50works23.72yr avg
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Research Topics

Immune cells in cancer(16), Epigenetics and DNA Methylation(9), Mitochondrial Function and Pathology(6), Immune Response and Inflammation(6), interferon and immune responses(6)

Publications50 total

An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice
Nature Communications·2025· 2 citedOpen Access
Macrophages say NO to nucleotide synthesis and salvage instead
Nature Metabolism·2025
Selective remodelling of the adipose niche in obesity and weight loss
Nature·2025· 27 citedOpen Access
Elucidating the mechanism of mitochondrial superoxide production in pro-inflammatory macrophages
Free Radical Biology and Medicine·2025
Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models
Frontiers in Immunology·2025· 1 citedOpen Access
Clinically translatable mitochondrial gene therapy in muscle using tandem mtZFN architecture
EMBO Molecular Medicine·2025· 6 citedOpen Access
Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation
Nature Metabolism·2025· 58 citedOpen Access
Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion
Science Advances·2025· 14 citedOpen Access
An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and <i>in vivo</i>
2025· 1 citedOpen Access
Chitinase-1 inhibition reverses metabolic dysregulation and restores homeostasis in MASH animal models
2024Open Access
High-dimensional single-cell analysis of human natural killer cell heterogeneity
Nature Immunology·2024· 185 citedOpen Access
Associations between TCA cycle plasma metabolites and fatigue in black females with systemic lupus erythematosus: An untargeted metabolomics pilot study
Lupus·2024· 4 citedOpen Access
Multifaceted mitochondria in innate immunity
npj Metabolic Health and Disease·2024· 55 citedOpen Access
High-Dimensional Single-Cell Analysis of Natural Killer Cell Heterogeneity in Human Blood
2024· 3 citedOpen Access
Chitinase-1 Inhibition Reverses Metabolic Dysregulation and Restores Homeostasis in MASH&amp;nbsp; Animal Models
SSRN Electronic Journal·2024Open Access
SUCCESSFUL VENO-ARTERIAL EXTRACORPOREAL CARDIOPULMONARY RESUSCITATION IN PERIPARTUM CARDIAC ARREST SECONDARY TO AMNIOTIC FLUID EMBOLISM
CHEST Journal·2023· 1 citedOpen Access
7: ECMO in community cardiac surgery program: comparable results?
ASAIO Journal·2023
Inflammatory mitochondrial nucleic acids as drivers of pathophysiology
Clinical and Translational Medicine·2023· 3 citedOpen Access
Immunometabolism at the basis of health and disease; an editorial
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2023· 2 citedOpen Access
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Nature·2023· 202 citedOpen Access
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Frequent Co-authors

Luke O'neill(24), Christian Frezza(20), Michael P. Murphy(13), Ming Yang(10), Alva M. Casey(8), Hiran A. Prag(7), Efterpi Nikitopoulou(7), Alex von Kriegsheim(7), Eloïse Marques(7), Ana S.H. Costa(6), Zbigniew Zasłona(6), Albena T. Dinkova‐Kostova(6), Elena V. Knatko(5), Laura Tronci(5), Ed C. Lavelle(5), Niamh C. Williams(5), Keira Turner(5), Jan Lj. Miljković(5), Christopher A. Powell(5), Michal Minczuk(5)