H. Sternlicht

Howard Hughes Medical Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index3.9kcitations69works0.02yr avg
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Research Topics

Microtubule and mitosis dynamics(16), Enzyme Structure and Function(9), Protein Structure and Dynamics(8), Carbohydrate Chemistry and Synthesis(8), Advanced NMR Techniques and Applications(8)

Publications69 total

Evidence That β-Tubulin Induces a Conformation Change in the Cytosolic Chaperonin Which Stabilizes Binding:  Implications for the Mechanism of Action<sup>,</sup>
Biochemistry·2000· 24 cited
Newly-Synthesized β-Tubulin Demonstrates Domain-Specific Interactions with the Cytosolic Chaperonin
Biochemistry·1996· 45 cited
The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo.
Proceedings of the National Academy of Sciences·1993· 348 citedOpen Access
Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region
Biophysical Journal·1993· 6 citedOpen Access
Site-directed mutagenesis of the GTP-binding domain of β-tubulin
Journal of Molecular Biology·1992· 25 cited
TCP1 complex is a molecular chaperone in tubulin biogenesis
Nature·1992· 466 cited
Alpha-tubulin influences nucleotide binding to beta-tubulin: an assay using picomoles of unpurified protein.
Proceedings of the National Academy of Sciences·1990· 13 citedOpen Access
Levuglandin E2 inhibits mitosis and microtubule assembly
Prostaglandins·1990· 29 cited
Kinetics of β-tubulin exchange following translation
Journal of Biological Chemistry·1989· 12 citedOpen Access
Ethoxyformylation of tubulin with [3H]diethyl pyrocarbonate: a reexamination of the mechanism of assembly inhibition
Biochemistry·1989· 6 cited
Translation of beta-tubulin mRNA in vitro generates multiple molecular forms.
Journal of Biological Chemistry·1988· 24 citedOpen Access
Expression of a human .alpha.-tubulin: properties of the isolated subunit
Biochemistry·1988· 31 cited
A model of the nucleotide‐binding site in tubulin
FEBS Letters·1987· 76 citedOpen Access
Microtubule assembly is dependent on a cluster of basic residues in .alpha.-tubulin
Biochemistry·1986· 41 cited
The Role of Lys 394 in Microtubule Assemblya
Annals of the New York Academy of Sciences·1986· 11 cited
Carbon-13 nuclear magnetic resonance study of microtubule protein: evidence for a second colchicine site involved in the inhibition of microtubule assembly
Biochemistry·1984· 52 cited
Theory for modeling the copolymerization of tubulin and tubulin-colchicine complex
Biophysical Journal·1983· 21 citedOpen Access
Identification of lysine residues essential for microtubule assembly. Demonstration of enhanced reactivity during reductive methylation.
Journal of Biological Chemistry·1983· 34 citedOpen Access
Inhibitors of Microtubule Formation
Cancer treatment and research·1983· 1 cited
Inhibitors of Microtubule Formation
Cancer treatment and research·1983
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Frequent Co-authors

Michael B. Yaffe(9), George W. Farr(9), C. Fred Brewer(6), J. Szasz(6), Mona L. Sternlicht(4), Israel Ringel(4), E. L. Packer(4), W. J. Horsley(3), D. M. Wilson(3), R. G. Shulman(3), Donald M. Marcus(3), Arthur P. Grollman(3), George L. Kenyon(3), G. C. Nieman(2), Giles Robinson(2), Jack S. Cohen(2), Harden M. McConnell(2), John D. Loike(2), Walter J. Gensler(2), E. W. Anderson(2)