Marco L. Lolli

Torino e-district — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index2.0kcitations131works8.32yr avg
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Research Topics

Biochemical and Molecular Research(43), HIV/AIDS drug development and treatment(21), Synthesis and Biological Evaluation(15), Synthesis and biological activity(10), Aldose Reductase and Taurine(9)

Publications129 total

Arzanol Inhibits Human Dihydroorotate Dehydrogenase and Shows Antiviral Activity
Journal of Natural Products·2025· 1 citedOpen Access
Fluorescent Isostere (<i>Fluostere</i>) of the Carboxylate: Design of <i>h</i>DHODH Fluorescent Inhibitors as Proof of Concept
Journal of Medicinal Chemistry·2025· 3 citedOpen Access
Novel benzophenone-, acetophenone-, and benzohydrazide-containing triazolopyrimidines as inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH): Design utilizing combined in silico approaches, synthesis, in vitro enzyme inhibition, and in vivo antimalarial activity
Journal of Molecular Structure·2025· 1 cited
Expanding the MR1 ligandome using chemical class-specific fragmentation and molecular networking
2025Open Access
DHODH inhibitors: What will it take to get them into the clinic as antivirals?
Antiviral Research·2025· 6 citedOpen Access
Off-Target Inhibition of Human Dihydroorotate Dehydrogenase (<i>h</i>DHODH) Highlights Challenges in the Development of Fat Mass and Obesity-Associated Protein (FTO) Inhibitors
ACS Pharmacology & Translational Science·2024· 7 citedOpen Access
322 Adipokines in psoriasis and obesity: emerging role of visfatin, leptin and adiponectin
Journal of Investigative Dermatology·2024Open Access
A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 2: Non-DSM compounds
Bioorganic Chemistry·2024· 5 cited
Author response for "Radiosynthesis of [18F]Brequinar for &lt;i&gt;in vivo&lt;/i&gt; PET Imaging of &lt;i&gt;h&lt;/i&gt;DHODH for Potential Studies of Acute Myeloid Leukemia and Cancers"
2024
AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications
ACS Medicinal Chemistry Letters·2024· 2 citedOpen Access
Insight in Quinazoline-based HDAC Inhibitors as Anti-cancer Agents
Mini-Reviews in Medicinal Chemistry·2024
An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent
Acta Crystallographica Section D Structural Biology·2024· 2 cited
Tandem mass spectrometry of homologous 3‐hydroxyfurazan and nitrile amino acids: Analysis of cooperative interactions and fragmentation processes
Journal of Mass Spectrometry·2024Open Access
A comprehensive review of synthetic strategies and SAR studies for the discovery of PfDHODH inhibitors as antimalarial agents. Part 1: triazolopyrimidine, isoxazolopyrimidine and pyrrole-based (DSM) compounds
Bioorganic Chemistry·2024· 13 cited
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer
European Journal of Medicinal Chemistry·2024· 9 citedOpen Access
Radiosynthesis of [ <sup>18</sup> F]brequinar for <i>in vivo</i> PET imaging of hDHODH for potential studies of acute myeloid leukemia and cancers
RSC Medicinal Chemistry·2024· 1 citedOpen Access
Radiosynthesis of [&lt;sup&gt;18&lt;/sup&gt;f]Brequinar for &lt;i&gt;in Vivo&lt;/i&gt; PET Imaging of &lt;i&gt;h&lt;/i&gt;DHODH in Acute Myeloid Leukemia and Cancers
SSRN Electronic Journal·2024Open Access
Intramolecular interactions and the neutral loss of ammonia from collisionally activated, protonated ω-aminoalkyl-3-hydroxyfurazans
European Journal of Mass Spectrometry·2023· 2 citedOpen Access
Mechanisms of antiviral activity of the new hDHODH inhibitor MEDS433 against respiratory syncytial virus replication
Antiviral Research·2023· 7 cited
Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis
Biomolecules·2023· 8 citedOpen Access
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Frequent Co-authors

Donatella Boschi(29), Agnese Chiara Pippione(21), Stefano Sainas(21), Barbara Rolando(14), Roberta Fruttero(12), Marta Giorgis(12), Alberto Gasco(11), Salam Al‐Karadaghi(7), Loretta Lazzarato(6), Davide Bonanni(6), Marco Piccinini(6), Simonetta Oliaro‐Bosso(6), Clara Cena(5), Parveen Goyal(5), Alex Ducime(5), Rosmarie Friemann(5), Klaus Pors(5), Renzo Bagnati(5), Alessandro Giraudo(5), Birgitte Nielsen(5)