Hamideh Parhiz

Translational Therapeutics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

26h-index4.7kcitations62works21.82yr avg
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Research Topics

RNA Interference and Gene Delivery(33), Advanced biosensing and bioanalysis techniques(15), Virus-based gene therapy research(13), CAR-T cell therapy research(10), Nanoparticle-Based Drug Delivery(5)

Publications62 total

Targeted Lipid Nanoparticle Delivery of FAP-CAR mRNA Enables Potent In Vivo T-Cell Engineering Against Pancreatic Tumors
Cancer Immunology Research·2026
Abstract WP340: From Neurovascular Challenge to Therapeutic Opportunity: VCAM-Targeted Nanocarriers in Acute Ischemic Stroke and Intracranial Hemorrhage
Stroke·2026
Rapid receptor internalization potentiates CD7-targeted lipid nanoparticles for efficient mRNA delivery to T cells and <i>in vivo</i> CAR T-cell engineering
2026· 1 citedOpen Access
Anti-FAP CAR T cells produced in vivo reduce fibrosis and restore liver homeostasis in metabolic dysfunction–associated steatohepatitis
Science Translational Medicine·2026· 2 cited
SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer
Carcinogenesis·2025
Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape
Nature Nanotechnology·2025· 28 citedOpen Access
Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo
Proceedings of the National Academy of Sciences·2025· 7 citedOpen Access
SRSF3 knockdown-induced cellular senescence as a possible therapeutic strategy for non-small cell lung cancer
2025Open Access
Abstract 3129: Fibroblast activation protein directed CAR T cells engineered <i>in situ</i> using targeted lipid nanoparticles inhibit progression of pancreatic ductal adenocarcinoma
Cancer Research·2025
In vivo anti-FAP CAR T therapy reduces fibrosis and restores liver homeostasis in metabolic dysfunction-associated steatohepatitis
2025· 6 citedOpen Access
In Situ Tumor Vaccination Using Lipid Nanoparticles to Deliver Interferon-β mRNA Cargo
Vaccines·2025· 3 citedOpen Access
An erythroid-specific lentiviral vector improves anemia and iron metabolism in a new model of XLSA
Blood·2024· 2 citedOpen Access
An Erythroid-Specific Lentiviral Vector Improves Anemia and Iron Metabolism in a New Model of Xlsa
Blood·2024
Use of HSC-targeted LNP to generate a mouse model of lethal α-thalassemia and treatment via lentiviral gene therapy
Blood·2024· 5 citedOpen Access
Translational Pharmacokinetic/Pharmacodynamic Modeling of Targeted mRNA-LNP Therapeutics
Journal of Pharmacology and Experimental Therapeutics·2024
Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape Without Side Effects
2024· 46 citedOpen Access
IL7 increases targeted lipid nanoparticle–mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation
Proceedings of the National Academy of Sciences·2024· 39 citedOpen Access
Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system
Molecular Therapy — Nucleic Acids·2024· 17 citedOpen Access
Targeting lipid nanoparticles to the blood-brain barrier to ameliorate acute ischemic stroke
Molecular Therapy·2024· 60 citedOpen Access
Oxidized mRNA Lipid Nanoparticles for In Situ Chimeric Antigen Receptor Monocyte Engineering
Advanced Functional Materials·2024· 40 citedOpen Access
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Frequent Co-authors

Tyler E. Papp(20), Vladimir R. Muzykantov(16), Drew Weissman(15), Mohammad Ramezani(14), Nagarajan Kandasamy(13), Barbara L. Mui(12), Vladimir V. Shuvaev(11), Ying K. Tam(11), Maryam Hashemi(11), Jacob W. Myerson(9), Oscar A. Marcos‐Contreras(9), Raisa Y. Kiseleva(8), Makan Khoshnejad(7), Amir Yadegari(6), Patrick M. Glassman(6), Ahad Mokhtarzadeh(6), Sara Amel Farzad(6), Fatemeh Soltani(5), Elizabeth D. Hood(5), Stefano Rivella(5)