Amanda Mikels‐Vigdal

Gilead Sciences (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index1.2kcitations23works0.02yr avg
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Research Topics

Microbial metabolism and enzyme function(8), Protease and Inhibitor Mechanisms(7), Peptidase Inhibition and Analysis(5), Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis(4), Neonatal Respiratory Health Research(3)

Publications23 total

Characterization of Active MMP9 in Chronic Inflammatory Diseases Using a Novel Anti-MMP9 Antibody
Antibodies·2023· 12 citedOpen Access
Translational Studies Reveal the Divergent Effects of Simtuzumab Targeting LOXL2 in Idiopathic Pulmonary Fibrosis
Fibrosis·2023· 5 citedOpen Access
Differential Responses to Targeting Matrix Metalloproteinase 9 in Idiopathic Pulmonary Fibrosis
American Journal of Respiratory and Critical Care Medicine·2020· 49 citedOpen Access
Wnt signaling and Loxl2 promote aggressive osteosarcoma
Cell Research·2020· 124 citedOpen Access
Targeting Lysyl oxidase-like 2 in Idiopathic Pulmonary Fibrosis
2019· 3 citedOpen Access
Transitional human alveolar type II epithelial cells suppress extracellular matrix and growth factor gene expression in lung fibroblasts
American Journal of Physiology-Lung Cellular and Molecular Physiology·2019· 19 citedOpen Access
Therapeutic efficacy of anti-MMP9 antibody in combination with nab-paclitaxel-based chemotherapy in pre-clinical models of pancreatic cancer
2019
Therapeutic efficacy of anti‐MMP9 antibody in combination with nab‐paclitaxel‐based chemotherapy in pre‐clinical models of pancreatic cancer
Journal of Cellular and Molecular Medicine·2019· 30 citedOpen Access
MMP-9 inhibition promotes anti-tumor immunity through disruption of biochemical and physical barriers to T-cell trafficking to tumors
PLoS ONE·2018· 102 citedOpen Access
TGF beta inhibits HGF, FGF7, and FGF10 expression in normal and IPF lung fibroblasts
Physiological Reports·2018· 27 citedOpen Access
Abstract 18: MMP9 inhibition in mouse models of breast cancer: Therapeutic synergy with vinorelbine-based chemotherapy
Cancer Research·2018· 2 cited
Abstract 4822: Anti-MMP9 antibody in combination with standard cytotoxic therapy in preclinical models of pancreatic cancer
Cancer Research·2018
Lysyl oxidase-like protein 2 (LOXL2) modulates barrier function in cholangiocytes in cholestasis
Journal of Hepatology·2018· 42 cited
TGF beta inhibits expression of SP-A, SP-B, SP-C, but not SP-D in human alveolar type II cells
Biochemical and Biophysical Research Communications·2018· 17 cited
Effect of andecaliximab (anti-MMP9) on proteolysis of IL-7 in vitro, TCR diversity in mice, and serum IL-7 in gastric cancer patients in combination with chemotherapy.
Journal of Clinical Oncology·2018· 2 cited
Abstract 653: Inhibition of MMP9 improves anti-tumor immunity by changing the tumor microenvironment to promote T cell trafficking and activation
Cancer Research·2017· 2 cited
Effect of MMP9 inhibition on effector T-cell responses in a PD1-axis refractory model.
Journal of Clinical Oncology·2017· 1 cited
Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
Gut·2017· 291 citedOpen Access
Targeting LOXL2 for cardiac interstitial fibrosis and heart failure treatment
Nature Communications·2016· 262 citedOpen Access
INCREASED LYSYL OXIDASE-LIKE 2 (LOXL2) CORRELATES WITH EJECTION FRACTION (EF) AND BNP IN HUMAN SYSTOLIC HEART FAILURE
Journal of the American College of Cardiology·2016
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Frequent Co-authors

Victoria Smith(12), Erin Stefanutti(5), Joanne I. Adamkewicz(4), Vladi Juric(4), Chris O’Sullivan(4), Andrew E. Greenstein(4), Hongyan Zhong(3), Susan K. Lyman(3), Maria Kovalenko(3), Vivian Barry-Hamilton(3), Igor Mikaelian(3), Jeremiah D. Degenhardt(3), Milena S. Espíndola(3), David M. Habiel(3), Ana Lúcia Coelho(3), Cory M. Hogaboam(3), Niranjan Awasthi(3), Margaret A. Schwarz(3), Sheena Monahan(3), Roderich E. Schwarz(3)