K. George Chandy

Nanyang Technological University — Singapore

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index3.7kcitations108works3.72yr avg
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Research Topics

Ion channel regulation and function(24), Immune Cell Function and Interaction(17), Cardiac electrophysiology and arrhythmias(12), T-cell and B-cell Immunology(8), CAR-T cell therapy research(7)

Publications108 total

Voltage-gated potassium channels (K<sub>v</sub>) in GtoPdb v.2025.4
IUPHAR/BPS Guide to Pharmacology CITE·2025Open Access
Structural basis for the subtype-selectivity of KCa2.2 channel activators
2025Open Access
Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel K <sub>Ca</sub> 3.1
Proceedings of the National Academy of Sciences·2025· 6 citedOpen Access
Haemodynamic stability during balanced total intravenous anaesthesia using fentanyl-propofol co-induction and maintenance with constant rate infusion of dexmedetomidine-fentanyl-lignocaine-ketamine along with variable rate infusion of propofol in dexmedetomidine-midazolam-ketamine premedicated dogs
International Journal of Veterinary Sciences and Animal Husbandry·2025Open Access
High Extracellular K <sup>+</sup> Skews T‐Cell Differentiation Towards Tumour Promoting Th2 and T <sub>reg</sub> Subsets
European Journal of Immunology·2024· 4 citedOpen Access
Author response for "High Extracellular K&lt;sup&gt;+&lt;/sup&gt; Skews T‐Cell Differentiation Towards Tumour Promoting Th2 and T&lt;sub&gt;reg&lt;/sub&gt; Subsets"
2024
Author response for "High Extracellular K&lt;sup&gt;+&lt;/sup&gt; Skews T‐Cell Differentiation Towards Tumour Promoting Th2 and T&lt;sub&gt;reg&lt;/sub&gt; Subsets"
2024
1387 Clinical relevance of spatially-resolved transcriptional signatures characterizing macrophages from the light and dark zone of the germinal centre
Regular and Young Investigator Award Abstracts·2024Open Access
Effect of Chlordiazepoxide or Haloperidol Oral Premedication during Midazolam-Ketamine Anaesthesia on Physiological and Blood Gas Parameters in Adult Male Bonnet Macaques (Macaca radiata)
Indonesian Journal of Primatology·2024Open Access
Effects of Midazolam-Ketamine Anesthesia on the Haematological and Biochemical Parameters Using Haloperidol or Chlordiazepoxide Premedication in Adult Male Bonnet Macaques (Macaca radiata)
Journal of Lab Animal Research·2024Open Access
High Extracellular K+ Drives T-Cell Exhaustion by Disrupting TCR Signals Implicated in Tumor Immune Evasion
Research Square (Research Square)·2024Open Access
Spatially-resolved transcriptomics reveal macrophage heterogeneity and prognostic significance in diffuse large B-cell lymphoma
Nature Communications·2024· 34 citedOpen Access
Spatially-Resolved Transcriptomics Define Clinically Relevant Subsets of Macrophages in Diffuse Large B-cell Lymphoma
2023Open Access
Augmenting the activity of calcium-activated potassium channel KCa3.1 revitalizes T-cell function in the immunosuppressive tumor microenvironment
Biophysical Journal·2023Open Access
Obstacles for T-lymphocytes in the tumour microenvironment: Therapeutic challenges, advances and opportunities beyond immune checkpoint
EBioMedicine·2022· 109 citedOpen Access
Mechanisms Underlying C-type Inactivation in Kv Channels: Lessons From Structures of Human Kv1.3 and Fly Shaker-IR Channels
Frontiers in Pharmacology·2022· 12 citedOpen Access
Imaging Kv1.3 Expressing Memory T Cells as a Marker of Immunotherapy Response
Cancers·2022· 13 citedOpen Access
A new kCa3.1 channel activator SKA-346 boosts T-cell antitumor response in the immune suppressive microenvironment
Biophysical Journal·2022
Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug
Proceedings of the National Academy of Sciences·2022· 49 citedOpen Access
Structures of wild-type and H451N mutant human lymphocyte potassium channel KV1.3
Cell Discovery·2021· 34 citedOpen Access
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Frequent Co-authors

Christine Beeton(8), George A. Gutman(7), Heike Wulff(6), Seow Theng Ong(5), Stephan Grissmer(4), B K Brightman(3), Nancy Waldeck(3), Bruce A. Buckingham(3), Ann K. Kershnar(3), Sudhir Gupta(3), David Burnett(3), Adriana Garcia(3), Michel Lazdunski(2), David McKinnon(2), Luis A. Pardo(2), Gail A. Robertson(2), Bernardo Rudy(2), Michael C. Sanguinetti(2), Walter Stühmer(2), Michael D. Cahalan(2)