Kolja Schleich

Charité - Universitätsmedizin Berlin — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index849citations20works0.02yr avg
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Research Topics

Cell death mechanisms and regulation(8), Telomeres, Telomerase, and Senescence(4), Epigenetics and DNA Methylation(3), CAR-T cell therapy research(3), NF-κB Signaling Pathways(3)

Publications20 total

Transcriptional repression of <i>NFKBIA</i> triggers constitutive IKK‐ and proteasome‐independent p65/RelA activation in senescence
The EMBO Journal·2021· 70 citedOpen Access
Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas
Blood·2020· 58 cited
H3K9me3-mediated epigenetic regulation of senescence in mice predicts outcome of lymphoma patients
Nature Communications·2020· 31 citedOpen Access
A novel IKK- and proteasome-independent mechanism of RelA activation triggers senescence associated secretome via transcriptional repression of NFKBIA
2019· 2 citedOpen Access
PERSONALIZED PREDICTION IN DLBCL ENABLED BY FUNCTIONAL MOUSE GENOMICS
Hematological Oncology·2019
Senescence Markers from a DLBCL-Reminiscent Mouse Lymphoma Model Predict Patient Outcome
Blood·2018
Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma
Cancer Cell·2018· 45 citedOpen Access
Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma
Cancer Cell·2018· 156 citedOpen Access
Mouse Lymphoma Model-Based Senescence Exploitation to Predict Treatment Outcome of DLBCL Patients
Blood·2017
Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma
Blood·2016· 14 citedOpen Access
Parameter identification using stochastic simulations reveals a robustness in CD95 apoptotic response
Molecular BioSystems·2016
Modeling the CNS Tropism of Diffuse Large B-Cell Lymphomas in Vivo
Blood·2015· 1 cited
Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain
Cell Death and Differentiation·2015· 77 citedOpen Access
CASP8 (Caspase 8, Apoptosis-Related Cysteine Peptidase)
Atlas of Genetics and Cytogenetics in Oncology and Haematology·2014· 1 citedOpen Access
Quantification of High-Molecular Weight Protein Platforms by AQUA Mass Spectrometry as Exemplified for the CD95 Death-Inducing Signaling Complex (DISC)
Cells·2013· 13 citedOpen Access
The chains of death
Cell Cycle·2013· 33 citedOpen Access
Mathematical modeling of apoptosis
Cell Communication and Signaling·2013· 39 citedOpen Access
Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model
Molecular Cell·2012· 189 citedOpen Access
Cellular FLICE-like inhibitory proteins (c-FLIPs): Fine-tuners of life and death decisions
Experimental Cell Research·2012· 109 cited
Systems Biology of Death Receptor-Induced Apoptosis
2012· 11 cited

Frequent Co-authors

Clemens A. Schmitt(11), Inna N. Lavrik(8), Philipp Lohneis(8), Yong Yu(6), Maurice Reimann(6), Soyoung Lee(6), Michael Hummel(5), Selcen Öztürk(4), Bernd Dörken(4), Maja Milanovic(4), Dorothy Ngo-Yin Fan(4), Jan R. Dörr(4), Ulf Leser(4), Uwe Warnken(3), Martina Schnölzer(3), Julia Kase(3), Saskia Trescher(3), Dido Lenze(3), Peter H. Krammer(2), Bin Yue(2)