John E.H. Tattersall

Defence Science and Technology Laboratory — United Kingdom

Agricultural and Biological Sciences · Life Sciences

26h-index2.0kcitations80works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Pesticide Exposure and Toxicity(35), Insect and Pesticide Research(27), Cholinesterase and Neurodegenerative Diseases(19), Neuroscience and Neuropharmacology Research(10), Ion channel regulation and function(10)

Publications80 total

Structure-activity studies of bispyridinium antinicotinics to select candidates to treat soman intoxication as part of a combined therapy
PLoS ONE·2025Open Access
Efficacy of the oxime HI-6 dimethanesulphonate in the treatment of guinea-pigs exposed to the nerve agents GB and GD
Toxicology Letters·2023· 1 citedOpen Access
Modelling organophosphate intoxication in C. elegans highlights nicotinic acetylcholine receptor determinants that mitigate poisoning
PLoS ONE·2023· 7 citedOpen Access
Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice
Toxics·2022· 4 citedOpen Access
A resonant cavity system for exposing cell cultures to intense pulsed RF fields
Scientific Reports·2022Open Access
Cholinergic signaling at the body wall neuromuscular junction distally inhibits feeding behavior in Caenorhabditis elegans
Journal of Biological Chemistry·2021· 14 citedOpen Access
Organophosphate intoxication in <i>C. elegans</i> reveals a new route to mitigate poisoning through the modulation of determinants responsible for nicotinic acetylcholine receptor function
2021Open Access
Cholinergic signalling at the body wall neuromuscular junction couples to distal inhibition of feeding in <i>C. elegans</i>
2021· 2 citedOpen Access
Molecular determinants of binding of non-oxime bispyridinium nerve agent antidote compounds to the adult muscle nAChR
Toxicology Letters·2021· 13 cited
C. elegans pharyngeal pumping provides a whole organism bio-assay to investigate anti-cholinesterase intoxication and antidotes
NeuroToxicology·2020· 18 cited
Influence of experimental end point on the therapeutic efficacy of the antinicotinic compounds MB408, MB442 and MB444 in treating nerve agent poisoned mice – a comparison with oxime-based treatment
Toxicology Mechanisms and Methods·2020· 5 cited
<i>C. elegans</i> pharyngeal pumping provides a whole organism bio-assay to investigate anti-cholinesterase intoxication and antidotes
2020· 1 citedOpen Access
3-Quinuclidinyl-α-methoxydiphenylacetate: A multi-targeted ligand with antimuscarinic and antinicotinic effects designed for the treatment of anticholinesterase poisoning
Toxicology Letters·2020· 5 cited
THE Caenorhabditis elegans PHARYNX AS A MODEL SYSTEM TO INVESTIGATE AND MITIGATE AGAINST THE EFFECTS OF ANTI-CHOLINESTERASE DRUGS
MMSL·2018
Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice
Toxicology·2018· 8 cited
Anticholinesterase toxicity
Current Opinion in Physiology·2018· 19 cited
Bioscavenger is effective as a delayed therapeutic intervention following percutaneous VX poisoning in the guinea-pig
Toxicology Letters·2017· 26 cited
The efficacy of HI-6 DMS in a sustained infusion against percutaneous VX poisoning in the guinea-pig
Toxicology Letters·2017· 11 cited
Evaluation of the Influence of Three Newly Developed Bispyridinium Anti‐nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice
Basic & Clinical Pharmacology & Toxicology·2017· 7 cited
Efficacy of the antinicotinic compound MB327 against soman poisoning – Importance of experimental end point
Toxicology Letters·2017· 14 cited
page 1 of 4Next →

Frequent Co-authors

Matthew E. Price(14), Christopher M. Timperley(14), A. Christopher Green(9), Mike Bird(8), Michael R. Bird(7), Simon R. Turner(6), Fernando Cerveró(5), Franz Worek(5), Patrick K. Harrison(4), Robert D. Sheridan(4), Karin V. Niessen(4), A.C. Green(4), Horst Thiermann(4), C. Whitmore(4), I.R. Duce(3), D.W.P. Thomas(3), Iain R. Scott(3), Bridget M. Lumb(3), Stuart J. Armstrong(3), Thomas Seeger(3)