William L. Rumsey

GlaxoSmithKline (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index4.5kcitations91works25.02yr avg
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Research Topics

Mitochondrial Function and Pathology(15), Adipose Tissue and Metabolism(13), Nitric Oxide and Endothelin Effects(11), Neuroscience of respiration and sleep(11), Receptor Mechanisms and Signaling(10)

Publications91 total

Cell-free DNA levels associate with COPD exacerbations and mortality
Respiratory Research·2024· 25 citedOpen Access
NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease
American Journal of Respiratory and Critical Care Medicine·2023· 71 citedOpen Access
Small molecule-mediated allosteric activation of the base excision repair enzyme 8-oxoguanine DNA glycosylase and its impact on mitochondrial function
Scientific Reports·2022· 20 citedOpen Access
Small Molecule-Mediated Allosteric Activation of the Base Excision Repair Enzyme 8-Oxoguanine DNA Glycosylase: Impact on Mitochondrial Function
Research Square (Research Square)·2022Open Access
Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protein Interaction
Journal of Medicinal Chemistry·2021· 32 citedOpen Access
Scientific Business Abstracts of the 113th Annual Meeting of the Association of Physicians of Great Britain and Ireland
QJM·2019· 1 citedOpen Access
Structure–Activity and Structure–Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein–Protein Interaction
Journal of Medicinal Chemistry·2019· 91 citedOpen Access
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
Nature Reviews Drug Discovery·2019· 1.3k citedOpen Access
3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent
ACS Medicinal Chemistry Letters·2018· 9 citedOpen Access
Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention
Free Radical Biology and Medicine·2018· 34 cited
Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists
American Journal of Respiratory and Critical Care Medicine·2018· 68 citedOpen Access
S115 Mechanisms to reverse impaired macrophage efferocytosis in copd
2017· 1 citedOpen Access
Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs
Mutagenesis·2016· 12 citedOpen Access
Small Molecule Ogg1 Activators Ameliorate mtDNA Oxidation and Promote Cell Health
The FASEB Journal·2016
Pharmacological Characterization of GSK573719 (Umeclidinium): A Novel, Long-Acting, Inhaled Antagonist of the Muscarinic Cholinergic Receptors for Treatment of Pulmonary Diseases
Journal of Pharmacology and Experimental Therapeutics·2013· 76 cited
4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy
Bioorganic & Medicinal Chemistry Letters·2012· 26 citedOpen Access
The pre-clinical pharmacology of the inhaled muscarinic antagonist GSK573719 predicts once-daily clinical dosing
2011· 15 cited
3,5-Disubstituted-indole-7-carboxamides: The discovery of a novel series of potent, selective inhibitors of IKK-β
Bioorganic & Medicinal Chemistry Letters·2011· 18 citedOpen Access
Progress Towards the Development of Anti-Inflammatory Inhibitors of IKKβ
Current Topics in Medicinal Chemistry·2009· 23 cited
Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β)
Journal of Medicinal Chemistry·2009· 30 citedOpen Access
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Frequent Co-authors

David F. Wilson(13), David Aharony(7), Jeffrey K. Kerns(6), Jeffrey S. Albert(6), Peter R Bernstein(6), Cyrus J. Ohnmacht(6), Paul Bamborough(5), Mary A. Morse(5), Russell Bialecki(5), James F. Callahan(4), Yolanda Sánchez(4), S. Lahiri(4), Rodrigo Iturriaga(4), J.A. Christopher(4), Herbert Barthlow(4), Bruce T. Dembofsky(4), Gerard M. Koether(4), W. M. Potts(4), Keith C. Russell(4), Jane M. Vanderkooi(3)