Sebastiano Trattaro

University of Milan — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index734citations30works16.82yr avg
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Research Topics

Single-cell and spatial transcriptomics(8), Pluripotent Stem Cells Research(6), RNA Research and Splicing(5), Congenital heart defects research(5), Genetics and Neurodevelopmental Disorders(5)

Publications30 total

A molecular cell atlas of endocrine signalling in human neural organoids
2025Open Access
Regulatory logic of human cortex evolution by combinatorial perturbations
2025Open Access
Disruption of ADNP-KDM1A-GTF2I complex drives neural differentiation imbalance in Helsmoortel-Van der Aa syndrome
2025Open Access
Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single-cell resolution
Nature Methods·2024· 23 citedOpen Access
Multiscale modeling uncovers 7q11.23 copy number variation–dependent changes in ribosomal biogenesis and neuronal maturation and excitability
Journal of Clinical Investigation·2024· 7 citedOpen Access
Brain Chimeroids reveal individual susceptibility to neurotoxic triggers
Nature·2024· 70 citedOpen Access
<i>GTF2I</i> dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders
Science Advances·2023· 31 citedOpen Access
Multi-donor human cortical Chimeroids reveal individual susceptibility to neurotoxic triggers
2023· 4 citedOpen Access
Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single cell resolution
2023· 4 citedOpen Access
Benchmarking brain organoid recapitulation of fetal corticogenesis
Translational Psychiatry·2022· 32 citedOpen Access
7q11.23 CNV alters protein synthesis and REST-mediated neuronal intrinsic excitability
2022· 9 citedOpen Access
GTF2I dosage regulates neuronal differentiation and social behavior in 7q11.23 neurodevelopmental disorders
2022· 4 citedOpen Access
EZH2-Mediated H3K27me3 Targets Transcriptional Circuits of Neuronal Differentiation
Frontiers in Neuroscience·2022· 21 citedOpen Access
Benchmarking brain organoid recapitulation of fetal corticogenesis
2022· 6 citedOpen Access
From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures
Science·2022· 262 citedOpen Access
Thymic stroma and TFII-I: towards new targeted therapies
Trends in Molecular Medicine·2021· 5 cited
AB012. Transcriptional and chromatin profiling reveals the molecular architecture and druggable vulnerabilities of thymic epithelial tumors (TETs)
Mediastinum·2021Open Access
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons
Molecular Autism·2020· 24 citedOpen Access
Dosage analysis of the 7q11.23 Williams region identifies BAZ1B as a major human gene patterning the modern human face and underlying self-domestication
Yearbook of pediatric endocrinology·2020· 6 cited
The sociability spectrum: evidence from reciprocal genetic copy number variations
Molecular Autism·2020· 19 citedOpen Access
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Frequent Co-authors

Giuseppe Testa(28), Nicolò Caporale(17), Alejandro Tobon(13), Erika Tenderini(11), Flavia Troglio(11), Cristina Cheroni(10), Alessandro Vitriolo(9), Carlo Emanuele Villa(9), Marco Tullio Rigoli(8), Adrianos Skaros(8), Matteo Zanella(7), Pierre‐Luc Germain(6), Reinald Shyti(6), Marija Mihailovich(6), Giuseppe D’Agostino(5), Michele Gabriele(5), Davide Castaldi(5), Raul Bardini Bressan(4), Francesca Cavallo(4), Steven M. Pollard(4)