Sandrine Thieffine

Medicine · Health Sciences

8h-index602citations14works0.02yr avg
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Research Topics

PARP inhibition in cancer therapy(3), Cancer-related gene regulation(3), Epigenetics and DNA Methylation(2), Enzyme Structure and Function(2), Cancer Treatment and Pharmacology(2)

Publications14 total

Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2
Journal of Biological Chemistry·2023· 8 citedOpen Access
Insights into PARP Inhibitors’ Selectivity Using Fluorescence Polarization and Surface Plasmon Resonance Binding Assays
SLAS DISCOVERY·2014· 20 citedOpen Access
Development of Biochemical Assays for the Identification of eIF4E-Specific Inhibitors
SLAS DISCOVERY·2012· 13 citedOpen Access
Identification of candidate substrates for poly(ADP‐ribose) polymerase‐2 (PARP2) in the absence of DNA damage using high‐density protein microarrays
FEBS Journal·2011· 29 citedOpen Access
Structural basis for CARM1 inhibition by indole and pyrazole inhibitors
Biochemical Journal·2011· 97 citedOpen Access
CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR
2010
Abstract 691: <i>In vitro</i> and <i>in vivo</i> characterization of selective orally available Parp-1 inhibitors with demonstrated antitumor efficacy in BRCA negative cancer models
Cancer Research·2010
Cell Division Cycle 7 Kinase Inhibitors: 1<i>H</i>-Pyrrolo[2,3-<i>b</i>]pyridines, Synthesis and Structure−Activity Relationships
Journal of Medicinal Chemistry·2009· 49 citedOpen Access
Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)
Bioorganic & Medicinal Chemistry Letters·2009· 80 citedOpen Access
Single Protocol for the Selective Isotopic and Chemical Labeling of Protein Kinases in Insect Cells for NMR and Crystallographic Studies
BioProcessing Journal·2004
Structural Characterization of the GSK-3β Active Site Using Selective and Non-selective ATP-mimetic Inhibitors
Journal of Molecular Biology·2003· 306 cited
GSK-3 Beta complexed with Inhibitor I-5
2003
GSK-3 Beta complexed with Indirubin-3'-monoxime
2003
GSK-3 Beta complexed with Alsterpaullone
2003

Frequent Co-authors

J. A. Bertrand(6), Cinzia Cristiani(5), Barbara Valsasina(5), Henryk M. Kalisz(5), Anna Vulpetti(4), Stefan Knapp(4), Maria M. Flocco(4), Federico Riccardi Sirtori(4), Tiziano Bandiera(3), Ashok V. Purandare(3), Sonia Troiani(3), Alessia Montagnoli(3), Rosita Lupi(3), Rita Perego(3), John S. Sack(2), Marina Fasolini(2), Gerald J. Duke(2), Lata Jayaraman(2), Kevin Kish(2), Herbert E. Klei(2)