Hesham Haffez

Helwan University — Egypt

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index343citations36works1.62yr avg
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Research Topics

Retinoids in leukemia and cellular processes(10), Synthesis and biological activity(5), Bioactive Compounds and Antitumor Agents(5), Cancer-related Molecular Pathways(4), Drug Transport and Resistance Mechanisms(3)

Publications36 total

Palbociclib in endocrine-resistant metastatic breast cancer patients: gene polymorphism- based study
Pharmacological Reports·2025
Palbociclib in endocrine-resistant metastatic breast cancer: real-world outcomes
Expert Review of Anticancer Therapy·2025
Scaffold-hopping strategy for pyrazolo[3,4-d]pyrimidines: In vitro and in silico studies of dual c-Met/STAT3 inhibition for enhanced antitumor activity
Bioorganic Chemistry·2025· 1 citedOpen Access
New Fluorescent Synthetic Retinoids as Potential RAR Agonists with Anticancer, Molecular Docking and ADME Assessments
Journal of Fluorescence·2025Open Access
Synergistic effects of abietic acid combined with doxorubicin on apoptosis induction in a human colorectal cancer cell line
Scientific Reports·2025· 3 citedOpen Access
Design and synthesis of novel Hydroxamate and non-Hydroxamate HDAC inhibitors based on Chromone and Quinazolone scaffolds
Bioorganic Chemistry·2025· 3 cited
Multiple Sclerosis: A Story of the Interaction Between Gut Microbiome and Components of the Immune System
Molecular Neurobiology·2025· 5 citedOpen Access
miRNA-sequencing and bioinformatics analyses of key miRNAs and their associated genes regulated by EC-synthetic retinoids treatment in Caco-2 cancer cells
Gene Reports·2025· 2 cited
Unravelling the potency of the 4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile scaffold with <i>S</i>-arylamide hybrids as PIM-1 kinase inhibitors: synthesis, biological activity and <i>in silico</i> studies
RSC Medicinal Chemistry·2025· 2 citedOpen Access
Anti-inflammatory potential of black cumin seed oil and its nanoemulsion formulation against lipopolysaccharide-induced liver injury in mice
Asian Pacific Journal of Tropical Biomedicine·2024· 1 citedOpen Access
Black cumin seed oil as inhibitor of cyclooxygenase-2 and 5-lipoxygenase in LPS-induced acute liver injury in mice
Egyptian Journal of Chemistry·2024· 1 cited
Novel <i>N</i> -Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations
Journal of Enzyme Inhibition and Medicinal Chemistry·2023· 6 citedOpen Access
New phenothiazine conjugates as apoptosis inducing agents: Design, synthesis, In-vitro anti-cancer screening and 131I-radiolabeling for in-vivo evaluation
Bioorganic Chemistry·2023· 9 cited
Common Applications of Black Cumin Seed (Nigella sativa) Oil in Folk Medicine
Journal of Advanced Pharmacy Research·2023· 6 citedOpen Access
Augmented Therapeutic Potential of EC-Synthetic Retinoids in Caco-2 Cancer Cells Using an In Vitro Approach
International Journal of Molecular Sciences·2022· 19 citedOpen Access
Role of single nucleotide polymorphisms of the HSD3B1 gene (rs6203 and rs33937873) in the prediction of prostate cancer risk
Molecular Medicine Reports·2022· 3 citedOpen Access
The potential roles of retinoids in combating drug resistance in cancer: implications of ATP-binding cassette (ABC) transporters
Open Biology·2022· 14 citedOpen Access
Author response for "The potential roles of retinoids in combating drug resistance in cancer: implications of ATP-binding cassette (ABC) transporters"
2022
Growth Inhibition and Apoptotic Effect of Pine Extract and Abietic Acid on MCF-7 Breast Cancer Cells via Alteration of Multiple Gene Expressions Using In Vitro Approach
Molecules·2022· 27 citedOpen Access
Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation
Frontiers in Immunology·2021· 57 citedOpen Access
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Frequent Co-authors

Sameh H. Soror(7), Christopher P.F. Redfern(6), David R. Chisholm(5), Roy Valentine(5), Ehmke Pohl(5), Stefan Przyborski(5), Mohamed R. Abdelaal(4), Natalie J. Tatum(4), Andrew Whiting(4), Shady Estfanous(3), Kylene P. Daily(3), Mostafa Eltobgy(3), Midhun N. K. Anne(3), Kathrin Krause(3), Asmaa Badr(3), Kaitlin Hamilton(3), Cierra Carafice(3), Arwa Abu Khweek(3), Xiaoli Zhang(3), Mikhail A. Gavrilin(3)