Simona Saponara

University of Siena — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index3.1kcitations109works3.82yr avg
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Research Topics

Ion channel regulation and function(28), Cardiac electrophysiology and arrhythmias(26), Neuroscience and Neuropharmacology Research(19), Drug Transport and Resistance Mechanisms(13), Phytochemicals and Antioxidant Activities(11)

Publications109 total

Targeting Class I Histone Deacetylases Triggers Antitumor Responses in Colorectal Cancer In Vitro and In Vivo
Journal of Medicinal Chemistry·2026
New Vanillyl-capped HDAC inhibitors exhibit anti-tumor efficacy in neuroblastoma and glioblastoma cells
Bioorganic Chemistry·2025· 2 cited
New dimension of ciprofloxacin hybrids: Synthesis, characterization and anticancer evaluation of newly C3-modified ciprofloxacin derivatives
Bioorganic Chemistry·2025Open Access
The insulin-releasing agent quercetin-3-oleate stimulates CaV1.2 channels similarly to quercetin, though with a reduced vasorelaxant activity
European Journal of Pharmacology·2025Open Access
New Dimension of Ciprofloxacin Hybrids: Synthesis, Characterization and Anticancer Evaluation of Newly C3-Modified Ciprofloxacin Derivatives
SSRN Electronic Journal·2025Open Access
Spirotetrahydroisoquinoline-Based Histone Deacetylase Inhibitors as New Antifibrotic Agents: Biological Evaluation in Human Fibroblasts from Bronchoalveolar Lavages of Idiopathic Pulmonary Fibrosis Patients
ACS Pharmacology & Translational Science·2024· 7 citedOpen Access
Screening of the antioxidant and vasorelaxant activity of wine waste ultrasonic extracts, and HRMS targeted and semi-targeted profiling of glycosylated polyphenols vs free polyphenols
LWT·2024· 2 citedOpen Access
A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound
Pharmacological Research·2024· 3 citedOpen Access
Targeting Relevant HDACs to Support the Survival of Cone Photoreceptors in Inherited Retinal Diseases: Identification of a Potent Pharmacological Tool with In Vitro and In Vivo Efficacy
Journal of Medicinal Chemistry·2024· 13 citedOpen Access
Development of Epigenetic Modifiers with Therapeutic Potential in FMS-Related Tyrosine Kinase 3/Internal Tandem Duplication (FLT3/ITD) Acute Myeloid Leukemia and Other Blood Malignancies
ACS Pharmacology & Translational Science·2024· 7 citedOpen Access
The Enigma of Norbormide, a Rattus-Selective Toxicant
Cells·2024· 2 citedOpen Access
Traceability and authentication in agri-food production: A multivariate approach to the characterization of the Italian food excellence elephant garlic (Allium ampeloprasum L.), a vasoactive nutraceutical
Food Chemistry·2024· 14 citedOpen Access
A Novel Combinatory Treatment Against a Cddp-Resistant Non-Small Cell Lung Cancer Based on a Ruthenium(Ii) Cyclopentadienyl Compound
SSRN Electronic Journal·2024Open Access
Nutritionally enriched tomatoes ( <i>Solanum lycopersicum</i> L.) grown with wood distillate: chemical and biological characterization for quality assessment
Journal of Food Science·2023· 23 citedOpen Access
Wine Lees as Source of Antioxidant Molecules: Green Extraction Procedure and Biological Activity
Antioxidants·2023· 18 citedOpen Access
Tyrosine Kinase Inhibitor Si409 Has In Vitro and In Vivo Anti-Tumor Activity Against Diffuse Large B-Cell Lymphoma
Pharmaceutical Chemistry Journal·2023· 2 cited
Artificial intelligence-driven identification of morin analogues acting as CaV1.2 channel blockers: Synthesis and biological evaluation
Bioorganic Chemistry·2022· 10 citedOpen Access
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions
European Journal of Medicinal Chemistry·2022· 15 citedOpen Access
Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels
Marine Drugs·2022· 22 citedOpen Access
Vietnamese Dalbergia tonkinensis: A Promising Source of Mono- and Bifunctional Vasodilators
Molecules·2022· 9 citedOpen Access
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Frequent Co-authors

Fabio Fusi(35), Giampietro Sgaragli(22), Beatrice Gorelli(14), Giuseppe Campiani(9), Sandra Gemma(8), Stefania Butini(8), Massimo Valoti(8), Gabriele Carullo(8), Alfonso Trezza(7), Ottavia Spiga(7), Simone Brogi(7), Stefania Lamponi(6), Francesca Aiello(6), Maria Frosini(5), Miriam Durante(5), Amer Ahmed(5), Chiara Riganti(4), Margherita Brindisi(4), P. Mugnai(4), Joanna Kopecka(3)