Leigh Busse

Amgen (United States) — United States

Medicine · Health Sciences

14h-index2.6kcitations23works0.02yr avg
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Research Topics

Erythropoietin and Anemia Treatment(13), Erythrocyte Function and Pathophysiology(5), Immune Response and Inflammation(4), 3D Printing in Biomedical Research(4), Virus-based gene therapy research(3)

Publications23 total

Functional EpoR Pathway Utilization Is Not Detected in Primary Tumor Cells Isolated from Human Breast, Non-Small Cell Lung, Colorectal, and Ovarian Tumor Tissues
PLoS ONE·2015· 22 citedOpen Access
Elliott 2006 Letters to ed
2015
Elliott 2006 Data Supplement
2015
Epo Receptors Are Not Detectable in Primary Human Tumor Tissue Samples
PLoS ONE·2013· 37 citedOpen Access
Lack of expression and function of erythropoietin receptors in the kidney
Nephrology Dialysis Transplantation·2011· 40 cited
Absence of Functional Epo Receptors In Normal and Cancerous Human Tissues and Cell Lines,
Blood·2011· 1 cited
Phosphatidylinositol-3 Kinase Delta (PI3Kδ) Inhibitor AMG 319 Is a Potent, Selective and Orally Bioavailable Small Molecule Inhibitor That Suppresses PI3K-Mediated Signaling and Viability in Neoplastic B Cells
Blood·2011· 4 cited
Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells
Blood·2010· 137 citedOpen Access
Identification of a sensitive anti-erythropoietin receptor monoclonal antibody allows detection of low levels of EpoR in cells
Journal of Immunological Methods·2009· 65 cited
Abstract #4283: Erythropoetin receptor (EpoR) was expressed at low to undetectable levels in tumor cell lines: Expression was not regulated by hypoxia and no epo-induced downstream signaling was detectable
Cancer Research·2009
Analysis of Cell Surface Erythropoietin Receptor (EpoR) Expression and Function in Epithelial Human Tumor Tissues Reveals No Detectable Cell Surface Expression or Function
Blood·2008
Erythropoietin receptor transcription is neither elevated nor predictive of surface expression in human tumour cells
British Journal of Cancer·2008· 65 citedOpen Access
Anti-Epo receptor antibodies do not predict Epo receptor expression
Blood·2005· 298 citedOpen Access
Control of rHuEPO biological activity: The role of carbohydrate
Experimental Hematology·2004· 198 cited
Is EPO Receptor Expressed in Human Tumor Cells?.
Blood·2004· 1 cited
Expression profiling of Epo receptor in non-hematopoietic tissues: implications for a direct effect of rHuEpo on cardiac cells
Journal of Cardiac Failure·2003
Enhancement of therapeutic protein in vivo activities through glycoengineering
Nature Biotechnology·2003· 510 cited
Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14
The Journal of Immunology·1996· 203 citedOpen Access
Identification of a Lipopolysaccharide Binding Domain in CD14 between Amino Acids 57 and 64
Journal of Biological Chemistry·1995· 119 citedOpen Access
Soluble CD14 Truncated at Amino Acid 152 Binds Lipopolysaccharide (LPS) and Enables Cellular Response to LPS
Journal of Biological Chemistry·1995· 86 citedOpen Access
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Frequent Co-authors

Steve Elliott(12), Angus M. Sinclair(10), C. Glenn Begley(7), Ian McCaffery(7), Gwyneth Van(6), Susan Swift(6), Henri S. Lichenstein(5), Norma Rogers(5), Eric Hailman(4), Samuel D. Wright(4), Ildiko Sarosi(4), Chris Spahr(4), John M. Rossi(4), Michael J. Kelley(3), Michael Bass(3), Hsieng S. Lu(3), Moonkyoung Um(3), Katherine Paweletz(3), John Rossi(3), David A. Johnson(2)