Joseph Santos‐Sacchi

Yale University — United States

Neuroscience · Life Sciences

43h-index6.8kcitations178works0.42yr avg
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Research Topics

Hearing, Cochlea, Tinnitus, Genetics(133), Hearing Loss and Rehabilitation(55), Acoustic Wave Phenomena Research(39), Vestibular and auditory disorders(30), Ion channel regulation and function(22)

Publications178 total

Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell
Structure·2025· 1 cited
Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell
Structure·2025Open Access
Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice
2025Open Access
BPS2025 - Conformational transition of prestin—the electro-mechanical transducer in outer hair cells of the inner ear
Biophysical Journal·2025
Chloride binding to prestin does not influence very high-frequency complex nonlinear capacitance (cNLC) in the mouse outer hair cell
2024· 1 citedOpen Access
Correction: Outer hair cell electromotility is low-pass filtered relative to the molecular conformational changes that produce nonlinear capacitance
The Journal of General Physiology·2023Open Access
Role of Ribeye PXDLS/T-binding cleft in normal synaptic ribbon function
2023Open Access
The biology of hearing and hearing loss: New insights from naked mole-rats into mechanisms and adaptive responses
The Journal of the Acoustical Society of America·2023
Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1/Tusc2 Knockout Model of Mitochondrial Dysfunction and Oxidative Stress
Antioxidants·2023· 6 citedOpen Access
Pharmacological Modulation of Energy and Metabolic Pathways Protects Hearing in the Fus1 KO Model of Mitochondrial Dysfunction and Oxidative Stress
Preprints.org·2023· 1 citedOpen Access
Megahertz Sampling of Prestin (SLC26a5) Voltage-Sensor Charge Movements in Outer Hair Cell Membranes Reveals Ultrasonic Activity that May Support Electromotility and Cochlear Amplification
Journal of Neuroscience·2023· 14 citedOpen Access
Ultrasonic measures of prestin (SLC26a5) charge movements in membrane patches
2022Open Access
Outer hair cell function is normal in βV spectrin knockout mice
Hearing Research·2022· 9 cited
On the frequency response of prestin charge movement in membrane patches
Biophysical Journal·2022· 8 citedOpen Access
Physiology and biophysics of outer hair cells: The cells of Dallos
Hearing Research·2022· 7 cited
Single particle cryo-EM structure of the outer hair cell motor protein prestin
Nature Communications·2022· 69 citedOpen Access
Phase tracking algorithms detect both real and imaginary components of outer hair cell nonlinear membrane capacitance that exhibits dielectric loss
2022· 1 citedOpen Access
Coupling between outer hair cell electromotility and prestin sensor charge depends on voltage operating point
Hearing Research·2021· 10 citedOpen Access
Genes related to SNPs identified by Genome-wide association studies of age-related hearing loss show restriction to specific cell types in the adult mouse cochlea
Hearing Research·2021· 18 cited
The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology
Biological reviews/Biological reviews of the Cambridge Philosophical Society·2021· 125 citedOpen Access
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Frequent Co-authors

Lei Song(9), Dhasakumar Navaratnam(7), Seiji Kakehata(6), Winston Tan(5), Jun-Ping Bai(4), Peter Dallos(3), Volodymyr Rybalchenko(2), George T.‐J. Huang(2), Amanda M. Lauer(2), Thomas J. Park(2), Sonja J. Pyott(2), Jing Zheng(2), Anthony J. Ricci(2), Caixia Lv(2), David Zenisek(2), Hong-Bo Zhao(2), Tama Hasson(1), Matthew B. Heintzelman(1), David P. Corey(1), Mark S. Mooseker(1)