Maikel Wijtmans

Vrije Universiteit Amsterdam — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

32h-index3.1kcitations106works2.12yr avg
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Research Topics

Receptor Mechanisms and Signaling(38), Chemokine receptors and signaling(23), Chemical Synthesis and Analysis(21), Photochromic and Fluorescence Chemistry(20), Mast cells and histamine(17)

Publications106 total

Author response for "Leveraging Fragment-Based Drug Discovery to Advance 3D Scaffolds into Potent Ligands: Application to the Histamine H<sub>1</sub> Receptor"
2026
Optical control of H1 receptor signaling with a BODIPY-photocaged antihistamine
Biochemical Pharmacology·2026Open Access
Leveraging fragment-based drug discovery to advance 3D scaffolds into potent ligands: application to the histamine H <sub>1</sub> receptor
RSC Medicinal Chemistry·2026Open Access
Inhibition of constitutive activity of the atypical chemokine receptor 3 by the small-molecule inverse agonist VUF16840
Molecular Pharmacology·2025· 2 citedOpen Access
Author response for "Design and synthesis of photoswitchable desloratadine ligands for histamine H&lt;sub&gt;1&lt;/sub&gt; receptor photopharmacology"
2025
Comparative analysis of molecular 3D metrics in fragment space and beyond
Drug Discovery Today·2025· 2 citedOpen Access
A Radiolabeled Photoswitchable G Protein-Coupled Receptor Antagonist Enlightens Ligand Binding Kinetics Associated with Photoswitching
Journal of the American Chemical Society·2025· 2 citedOpen Access
Photo-clenbuterol: Optical Control of β<sub>2</sub>-Adrenergic Receptor Signaling by Photoswitchable Ligand Efficacy
Journal of Medicinal Chemistry·2025· 3 citedOpen Access
Recent Developments in the Optical Control of Adrenergic Signaling
Medicinal Research Reviews·2025· 4 citedOpen Access
Design, Synthesis and Pharmacological Characterization of the First Photoswitchable Small-Molecule Agonist for the Atypical Chemokine Receptor 3
ACS Omega·2025· 1 citedOpen Access
Optical control of H1 receptor signaling with a BODIPY- photocaged antihistamine
SSRN Electronic Journal·2025Open Access
Design and synthesis of photoswitchable desloratadine ligands for histamine H <sub>1</sub> receptor photopharmacology
RSC Medicinal Chemistry·2025· 2 citedOpen Access
Inhibition of constitutive activity of the atypical chemokine receptor ACKR3 by the small-molecule inverse agonist VUF16840
2024Open Access
Probing the Histamine H<sub>1</sub> Receptor Binding Site to Explore Ligand Binding Kinetics
Journal of Medicinal Chemistry·2024· 2 citedOpen Access
High‐Pressure‐Mediated Fragment Library Synthesis of 1,2‐Disubsituted Cyclobutane Derivatives
European Journal of Organic Chemistry·2024· 2 citedOpen Access
The Role of Water Networks in Phosphodiesterase Inhibitor Dissociation and Kinetic Selectivity
ChemMedChem·2024Open Access
A high-affinity, cis-on photoswitchable beta blocker to optically control β2-adrenergic receptors in vitro and in vivo
Biochemical Pharmacology·2024· 5 citedOpen Access
Synthesis and Pharmacological Characterization of New Photocaged Agonists for Histamine H3 and H4 Receptors
Pharmaceuticals·2024· 5 citedOpen Access
Design, synthesis and pharmacological characterization of the first photoswitchable small-molecule agonist for the Atypical Chemokine Receptor 3
2024· 1 citedOpen Access
Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3
Molecular Pharmacology·2024· 12 citedOpen Access
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Frequent Co-authors

Iwan J. P. de Esch(35), Rob Leurs(32), Chris de Graaf(13), Martine J. Smit(12), Henry F. Vischer(11), Danny J. Scholten(6), Ned A. Porter(6), H. Lingeman(6), Meritxell Canals(5), W.M.A. Niessen(5), Hubertus Irth(5), Hans Custers(5), Sebastiaan Kuhne(5), Luc Roumen(4), Derek A. Pratt(4), Jeroen Kool(4), Albert J. Kooistra(4), Luca Valgimigli(3), Gian Franco Pedulli(3), Mark Eggink(3)