Véronique Trochon-Joseph

Onxeo (France) — France

Medicine · Health Sciences

6h-index338citations19works0.02yr avg
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Research Topics

PARP inhibition in cancer therapy(6), DNA Repair Mechanisms(4), CRISPR and Genetic Engineering(3), Nanoparticle-Based Drug Delivery(2), Cancer Immunotherapy and Biomarkers(2)

Publications19 total

Anticancer effects of PARP1 hyperactivation by a decoy oligodeoxynucleotide in vitro and in vivo.
Journal of Clinical Oncology·2022
6MO Translational relevance of the combined treatment PARP inhibitors and AsiDNA in homologous recombination proficient tumors
Annals of Oncology·2022Open Access
Abstract 1433: Acquired resistance to KRASG12C inhibitors evolves from drug tolerant cells vulnerable to AsiDNA
Cancer Research·2021
Abstract 527: A new generation of PARP interfering drug candidates for cancer treatment
Cancer Research·2021
6P AsiDNA targets drug-tolerant persister cells responsible of resistance to PARP inhibitors
Annals of Oncology·2021Open Access
A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours
British Journal of Cancer·2020· 7 citedOpen Access
21P OX401, a new generation of PARP-interfering drug for cancer treatment
Annals of Oncology·2020
Enhanced anti-tumor efficacy of checkpoint inhibitors in combination with the histone deacetylase inhibitor Belinostat in a murine hepatocellular carcinoma model
Cancer Immunology Immunotherapy·2018· 136 citedOpen Access
Abstract 2818: AsiDNA and HDAC inhibitors: A cross-potentiation team working to kill tumor cells
Cancer Research·2018
Biodistribution of polycyanoacrylate nanoparticles encapsulating doxorubicin by Matrix-Assisted Laser Desorption Ionization (MALDI) Mass Spectrometry Imaging (MSI)
Journal of Drug Delivery Science and Technology·2018· 16 cited
Abstract 1059: Enhanced anti-tumor efficacy of a checkpoint inhibitor in combination with the HDAC inhibitor belinostat in a murine hepato-cellular carcinoma preclinical model
Cancer Research·2017· 1 cited
Abstract 3076: A novel nanoparticle formulation of doxorubicin is clearly differentiated from free doxorubicin in overcoming resistance mechanisms in chemo-resistant tumors
Cancer Research·2017
Abstract 2143: Mechanistic study of the relative cytotoxicity of doxorubicin loaded nanoparticle formulation compared to free doxorubicin in hepatocellular carcinoma (HCC) cell lines
Cancer Research·2016· 4 cited
Effect of clonidine on proinflammatory cytokine levels in ex vivo human oral mucosa.
Journal of Clinical Oncology·2014· 2 cited
Effect of topical clonidine on the duration and severity of radiation-induced oral mucositis (OM) in a translational hamster model.
Journal of Clinical Oncology·2014· 4 cited
Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine psoriasiform skin lesions
Journal of Clinical Investigation·2010· 40 citedOpen Access
Evidence of Antiangiogenic and Antimetastatic Activities of the Recombinant Disintegrin Domain of Metargidin
Cancer Research·2004· 96 citedOpen Access
Evidence of antiangiogenic and antimetastatic activities of the recombinant disintegrin domain of metargidin.
HAL (Le Centre pour la Communication Scientifique Directe)·2004· 5 cited
Coelectrotransfer to skeletal muscle of three plasmids coding for antiangiogenic factors and regulatory factors of the tetracycline-inducible system: tightly regulated expression, inhibition of transplanted tumor growth, and antimetastatic effect
Molecular Therapy·2003· 27 cited

Frequent Co-authors

Wael Jdey(8), Vincent Hayes(8), Christelle Zandanel(7), Françoise Bono(5), Caroline Lemarchand(5), Graham Dixon(4), Lluis M. Mir(4), Chloé Doizelet(4), Perrine Pivette(3), B. Vasseur(3), Dominique Martel-Renoir(3), Paule Opolon(3), Elisabeth Connault(3), Michel Perricaudet(3), Jean‐Louis Labernardière(3), Marie-Christine Lienafa(3), Diana Llópiz(2), Marta Ruiz(2), Bruno Sangro(2), Pablo Sarobe(2)