René Fuertig

Boehringer Ingelheim (Germany) — Germany

Neuroscience · Life Sciences

10h-index480citations18works4.02yr avg
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Research Topics

Stress Responses and Cortisol(6), Tryptophan and brain disorders(5), Neuropeptides and Animal Physiology(2), Ion Channels and Receptors(2), Neuroinflammation and Neurodegeneration Mechanisms(2)

Publications18 total

TRPC4/5 inhibitors: Phase I results and proof of concept studies
European Archives of Psychiatry and Clinical Neuroscience·2024· 4 citedOpen Access
Effect of BI 1358894 on Cholecystokinin-Tetrapeptide (CCK-4)-Induced Anxiety, Panic Symptoms, and Stress Biomarkers: A Phase I Randomized Trial in Healthy Males
CNS Drugs·2023· 12 citedOpen Access
Effects of Single and Multiple Ascending Doses of BI 1358894 in Healthy Male Volunteers on Safety, Tolerability and Pharmacokinetics: Two Phase I Partially Randomised Studies
CNS Drugs·2023· 12 citedOpen Access
The effects of transient receptor potential cation channel inhibition by BI 1358894 on cortico-limbic brain reactivity to negative emotional stimuli in major depressive disorder
European Neuropsychopharmacology·2022· 19 citedOpen Access
P.449 Relative bioavailability of a single oral dose BI 1358894 administered alone or in combination with multiple oral doses of itraconazole
European Neuropsychopharmacology·2020· 1 cited
P.447 Multiple rising doses of oral BI 1358894 in healthy male volunteers: a phase I study investigating safety, tolerability and pharmacokinetics
European Neuropsychopharmacology·2020· 2 cited
P.450 A phase I single-rising-dose study of oral BI 1358894 in healthy male volunteers: safety, pharmacokinetics and food effect
European Neuropsychopharmacology·2020· 2 cited
P.448 BI 1358894 attenuates cholecystokinin tetrapeptide (CCK-4) induced anxiety and panic symptoms in healthy male volunteers
European Neuropsychopharmacology·2020· 2 cited
Multiple Rising Doses of Oral BI 1358894 in Healthy Male Volunteers: A Phase I Study to Investigate Safety and Tolerability
Biological Psychiatry·2020· 1 cited
First-In-Human Study of Oral BI 1358894 in Healthy Male Volunteers: A Phase I Study to Investigate Safety and Tolerability
Biological Psychiatry·2020· 2 cited
Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours
British Journal of Cancer·2020· 40 citedOpen Access
Phase I dose‐escalation study of volasertib in pediatric patients with acute leukemia or advanced solid tumors
Pediatric Blood & Cancer·2019· 13 citedOpen Access
LC–MS/MS-Based Quantification of Kynurenine Metabolites, Tryptophan, Monoamines and Neopterin in Plasma, Cerebrospinal Fluid and Brain
Bioanalysis·2016· 149 citedOpen Access
Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice
Brain Behavior and Immunity·2016· 36 citedOpen Access
Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase
Brain Behavior and Immunity·2015· 134 citedOpen Access
CD40-TNF activation in mice induces extended sickness behavior syndrome co-incident with but not dependent on activation of the kynurenine pathway
Brain Behavior and Immunity·2015· 33 citedOpen Access
EPA-1343 – Chronic psychosocial stress in mice causes neuro-immune-monoamine changes in brain and depression-relevant behaviour that is reversible by anti-inflammatory treatment
European Psychiatry·2014
A novel liquid chromatography/tandem mass spectrometry method for the quantification of glycine as biomarker in brain microdialysis and cerebrospinal fluid samples within 5min
Journal of Chromatography B·2013· 18 cited

Frequent Co-authors

Markus Goettel(8), Vikas Sharma(7), Angelo Ceci(4), Bastian Hengerer(4), Hannes Sigrist(4), Erich Seifritz(4), Christopher R. Pryce(4), Lena Herich(4), Andreas H. Luippold(3), Damiano Azzinnari(3), Stefan Just(3), Salome Rebecca Mack(3), Andreas Wunder(3), Sabrina Wiebe(3), Giorgio Bergamini(2), Flurin Cathomas(2), A. Fontana(2), Simone Grimm(2), Johan den Boer(2), Josef Höfler(2)