Eric C. Holland

Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa — South Africa

Medicine · Health Sciences

94h-index38.2kcitations525works5.62yr avg
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Research Topics

Glioma Diagnosis and Treatment(257), Cancer, Hypoxia, and Metabolism(56), MicroRNA in disease regulation(40), Cancer Cells and Metastasis(37), Hedgehog Signaling Pathway Studies(34)

Publications523 total

BIOM-113. TERT EXPRESSION IN MENINGIOMAS PREDICTS PROGRESSION-FREE SURVIVAL INDEPENDENT OF TERT PROMOTER MUTATION
Neuro-Oncology·2025Open Access
Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology
Neuro-Oncology·2025Open Access
Analysis of TERT association with clinical outcome in meningiomas: a multi-institutional cohort study
The Lancet Oncology·2025· 4 cited
C-terminal fusion partner activity contributes to the oncogenic functions of YAP1::TFE3
Scientific Reports·2025Open Access
Seq-ing answers: exploring meningioma biology utilizing bulk RNA-seq-based reference landscapes
Frontiers in Oncology·2025· 1 citedOpen Access
33 TERT EXPRESSION PREDICTS PROGRESSION-FREE SURVIVAL IN MENINGIOMAS
Neuro-Oncology Advances·2025Open Access
Development of PROTACs for targeted degradation of oncogenic TRK fusions
2025Open Access
Abstract 6511: Immunocompetent large animal model of mesenchymal glioblastoma achieved through somatic gene editing technology
Cancer Research·2025
Abstract 4592: TERT expression predicts progression-free survival in meningiomas
Cancer Research·2025
Molecular signatures define <i>BAP1</i>-altered meningioma as a distinct CNS tumor with deregulation of Polycomb repressive complex target genes
Neuro-Oncology·2025· 11 citedOpen Access
C-terminal fusion partner activity contributes to the oncogenic functions of YAP1::TFE3
2025· 1 citedOpen Access
2091 Molecular Classification Refines Surgical and Radiotherapeutic Decision Making in Meningioma and Prospective Validation
Neurosurgery·2025· 1 cited
RNA polymerase II at histone genes predicts outcome in human cancer
Science·2025· 27 citedOpen Access
A Systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas
2025· 1 citedOpen Access
EPCO-30. TRANSCRIPTOMIC ANALYSIS IDENTIFIES REGIONAL BIOLOGY AND OUTCOME HETEROGENEITY IN MEDULLOBLASTOMA AND EPENDYMOMA SUBTYPES
Neuro-Oncology·2024Open Access
CSIG-08. AGGRESSIVE HIGH-GRADE NF2 MUTANT MENINGIOMAS DOWNREGULATE ONCOGENIC YAP SIGNALING VIA THE UPREGULATION OF VGLL4 AND FAT3/4
Neuro-Oncology·2024Open Access
Integrated transcriptomic landscape of medulloblastoma and ependymoma reveals novel tumor subtype-specific biology
2024· 1 citedOpen Access
PL02.3.A MOLECULAR CLASSIFICATION TO REFINE SURGICAL AND RADIOTHERAPEUTIC DECISION MAKING IN MENINGIOMA
Neuro-Oncology·2024Open Access
ERK signaling promotes resistance to TRK kinase inhibition in NTRK fusion-driven glioma mouse models
Cell Reports·2024· 6 citedOpen Access
HOXD12 defines an age-related aggressive subtype of oligodendroglioma
Acta Neuropathologica·2024· 5 citedOpen Access
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Frequent Co-authors

Dolores Hambardzumyan(8), Jason T. Huse(7), Cameron Brennan(7), Oren J. Becher(5), Johanna A. Joyce(4), Kenneth Aldape(4), Richard J. Gilbertson(4), Chengkai Dai(4), Gregory N. Fuller(4), Nikki Charles(4), Marc K. Rosenblum(4), Raymond Sawaya(3), Joseph Celestino(3), Andreas von Deimling(3), Anne-Marie Bleau(3), Tatsuya Ozawa(3), Elena I. Fomchenko(3), Meena K. Tanwar(3), Alan H. Shih(3), Ziya L. Gokaslan(2)