Daniel Little

Great Ormond Street Hospital for Children NHS Foundation Trust — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index2.2kcitations31works0.02yr avg
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Research Topics

Pluripotent Stem Cells Research(8), Parkinson's Disease Mechanisms and Treatments(7), CRISPR and Genetic Engineering(7), Mitochondrial Function and Pathology(5), Neuroscience and Neural Engineering(4)

Publications31 total

Pilot Study of Fingolimod Treatment in Neuronal Ceroid Lipofuscinosis Type 1
Neurology Genetics·2026Open Access
High Content Analysis of Mitochondrial Function in Induced Pluripotent Stem Cell-Derived Neurons
Methods in molecular biology·2025
Characterization of two human induced pluripotent stem cell lines derived from Batten disease patient fibroblasts harbouring CLN5 mutations
Stem Cell Research·2023· 2 citedOpen Access
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
Nature Neuroscience·2022· 227 citedOpen Access
Structural conversion of α-synuclein at the mitochondria induces neuronal toxicity
2022Open Access
Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Cell Death and Differentiation·2020· 9 citedOpen Access
Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Cell Death and Differentiation·2020· 5 citedOpen Access
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Cell Death and Differentiation·2020· 285 citedOpen Access
Using stem cell–derived neurons in drug screening for neurological diseases
Neurobiology of Aging·2019· 57 cited
Seeding Induced Pluripotent Stem Cell-Derived Neurons onto 384-Well Plates
Methods in molecular biology·2019· 3 cited
High-Content Analysis of Mitochondrial Function in iPSC-Derived Neurons
Methods in molecular biology·2019· 4 cited
High-Content Autophagy Analysis in iPSC-Derived Neurons Using Immunofluorescence
Methods in molecular biology·2019· 2 cited
Preparation of iPSCs for Targeted Proteomic Analysis
Methods in molecular biology·2019· 1 cited
An Optimized Method for the Proteomic Analysis of Low Volumes of Cell Culture Media and the Secretome: The Application and the Demonstration of Altered Protein Expression in iPSC-Derived Neuronal Cell Lines from Parkinson’s Disease Patients
Journal of Proteome Research·2018· 2 cited
A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA
Scientific Reports·2018· 65 citedOpen Access
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease
Nature Communications·2018· 490 citedOpen Access
Overproduction of reactive oxygen species is the primary pathological event related to neuronal cell death in iPSC derived neurons from patients with familial Parkinson's disease
Free Radical Biology and Medicine·2018· 3 cited
Mouse decellularised liver scaffold improves human embryonic and induced pluripotent stem cells differentiation into hepatocyte-like cells
PLoS ONE·2017· 29 citedOpen Access
Agrobacterium- and Biolistic-Mediated Transformation of Maize B104 Inbred
Methods in molecular biology·2017· 35 cited
α-Synuclein binds to the ER–mitochondria tethering protein VAPB to disrupt Ca2+ homeostasis and mitochondrial ATP production
Acta Neuropathologica·2017· 350 citedOpen Access
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Frequent Co-authors

Paul Gissen(21), Michael J. Devine(14), Andrey Y. Abramov(10), Sonia Gandhi(10), Plamena R. Angelova(8), Mathew H. Horrocks(8), David Klenerman(8), Minee L. Choi(7), Olukunbi Mosaku(7), Margarida Rodrigues(6), Alexey V. Berezhnov(6), Tilo Kunath(6), Robin Ketteler(6), Suman De(5), Christin Luft(5), Ratsuda Yapom(4), Karamjit Singh Dolt(4), Evgeny V. Pavlov(4), Mimoun Azzouz(4), Wendy Heywood(4)