Michael A. Laflamme

University Health Network — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

43h-index15.6kcitations125works4.32yr avg
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Research Topics

Pluripotent Stem Cells Research(63), Tissue Engineering and Regenerative Medicine(52), Neuroscience and Neural Engineering(28), Congenital heart defects research(26), CRISPR and Genetic Engineering(20)

Publications125 total

Bright Ferritin for Non-Invasive MRI Monitoring of the Fate of Transplanted hPSC-Cardiomyocytes in the Infarcted Rat Heart.
PubMed·2026
Generation of Valvular Interstitial Cells from Human Pluripotent Stem Cells
2025· 1 cited
Cardiac MRI Reveals Matured Pluripotent Stem Cell-Derived Cardiomyocyte Therapy Attenuates Adverse Remodelling in Guinea Pigs
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition·2025
Growth Factor-Based Manufacturing of Human Pluripotent Stem Cell-Derived Cardiomyocytes Using the Vertical Wheel Bioreactor System
2025Open Access
Human pluripotent stem cell-derived atrioventricular node-like pacemaker cells exhibit biological conduction bridge properties in vitro and in vivo
2025Open Access
Protocol for dual-optical mapping of voltage and calcium sensors in human pluripotent stem cell-derived cardiomyocytes
STAR Protocols·2025· 3 citedOpen Access
Abstract Thu035: Growth Factor-Based Manufacturing of Human Pluripotent Stem Cell-Derived Cardiomyocytes Using the Vertical Wheel Bioreactor System
Circulation Research·2025
Integral membrane-shaping proteins drive sarco(endo)plasmic reticulum formation and maturation during cardiomyocyte development
Journal of Molecular and Cellular Cardiology Plus·2025Open Access
Human pluripotent stem cell-based cardiac repair: Lessons learned and challenges ahead
Advanced Drug Delivery Reviews·2025· 4 cited
Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes
Nature Communications·2024· 5 citedOpen Access
Assessing Myocardial Microvascular Reactivity with a Novel MRI Blood-Pool Imaging Approach
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition·2024
A Novel MRI Platform for Long-term Stem Cell Tracking In Vivo
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition·2024· 1 cited
Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias
Frontiers in Cardiovascular Medicine·2024· 4 citedOpen Access
FAST-STEM: A human pluripotent stem cell engineering toolkit for rapid design-build-test-learn development of human cell-based therapeutic devices
2024· 4 citedOpen Access
Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways
Nature Cardiovascular Research·2024· 43 citedOpen Access
Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Biomolecules·2024· 9 citedOpen Access
Using diffusion tensor imaging to depict myocardial changes after matured pluripotent stem cell-derived cardiomyocyte transplantation
Journal of Cardiovascular Magnetic Resonance·2024· 3 citedOpen Access
FAST-STEM: Synthetic Biology Toolkit for Next Generation Regenerative Medicine
SSRN Electronic Journal·2024Open Access
Itaconate and citrate releasing polymer attenuates foreign body response in biofabricated cardiac patches
Materials Today Bio·2023· 11 citedOpen Access
Bright ferritin for long-term MR imaging of human embryonic stem cells
Stem Cell Research & Therapy·2023· 4 citedOpen Access
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Frequent Co-authors

Charles E. Murry(20), Wei-Zhong Zhu(8), Joseph Gold(7), Hans Reinecke(6), Elina Minami(6), Gordon Keller(6), Veronica Muskheli(5), Benjamin Van Biber(5), Stéphane Massé(5), Kumaraswamy Nanthakumar(5), Chunhui Xu(4), James A. Fugate(3), Sarah Dupras(3), Mohammad Hassanipour(3), Shailaja Police(3), Jay A. Gantz(3), Lil Pabon(3), Sara S. Nunes(3), Yuji Shiba(3), Sarah Fernandes(3)