Maija Lahtela‐Kakkonen

University of Eastern Finland — Finland

Medicine · Health Sciences

32h-index4.0kcitations92works3.62yr avg
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Research Topics

Sirtuins and Resveratrol in Medicine(33), Computational Drug Discovery Methods(15), Calcium signaling and nucleotide metabolism(10), PARP inhibition in cancer therapy(8), Autophagy in Disease and Therapy(7)

Publications92 total

CYP1B1 Knockout in a Bovine Hepatocyte-like Cell Line (BFH12) Unveils Its Role in Liver Homeostasis and Aflatoxin B1-Induced Hepatotoxicity
Toxins·2025Open Access
Screening of phenolic antibacterial compounds for the prevention of biofouling
Journal of Molecular Structure·2025· 5 citedOpen Access
Impact of Missense Mutations on AFB1 Metabolism in Bovine Cytochrome P4503A Isoforms: A Computational Mutagenesis and Molecular Docking Analysis
International Journal of Molecular Sciences·2024Open Access
Novel inhibitors of bromodomain and extra-terminal domain trigger cell death in breast cancer cell lines
Bioorganic & Medicinal Chemistry·2024· 1 citedOpen Access
TRPA1 Inhibition Effects by 3-Phenylcoumarin Derivatives
ACS Medicinal Chemistry Letters·2024· 4 citedOpen Access
New insights into aflatoxin B1 mechanistic toxicology in cattle liver: an integrated approach using molecular docking and biological evaluation in CYP1A1 and CYP3A74 knockout BFH12 cell lines
Archives of Toxicology·2024· 11 citedOpen Access
5-Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions
Journal of Medicinal Chemistry·2024· 11 citedOpen Access
Integrative Framework for Developing Innovative SIRT2 Inhibitors
FarFar - Pharmacy Repository·2024Open Access
DEVELOPMENT OF AN INTEGRATIVE PLATFORM FOR DESIGN OF NOVEL SIRT2 INHIBITORS
2024
Dynamics behavior of PE and PET oligomers in lipid bilayer simulations
Microplastics and Nanoplastics·2023· 3 citedOpen Access
SIRT2i_Predictor: A Machine Learning-Based Tool to Facilitate the Discovery of Novel SIRT2 Inhibitors
Pharmaceuticals·2023· 7 citedOpen Access
Micro-sized polyethylene particles affect cell viability and oxidative stress responses in human colorectal adenocarcinoma Caco-2 and HT-29 cells
The Science of The Total Environment·2023· 63 citedOpen Access
SIRT2i_Predictor: A machine learning-based tool to facilitate the discovery of novel SIRT2 inhibitors
2022Open Access
Expanding the Accessible Chemical Space of SIRT2 Inhibitors through Exploration of Binding Pocket Dynamics
Journal of Chemical Information and Modeling·2022· 14 cited
PE and PET oligomers’ interplay with membrane bilayers
Scientific Reports·2022· 23 citedOpen Access
Profiling the regulatory interplay of BET bromodomains and Sirtuins in cancer cell lines
Biomedicine & Pharmacotherapy·2022· 5 citedOpen Access
Expanding the Accessible Chemical Space of SIRT2 Inhibitors through Exploration of Binding Pocket Dynamics
FarFar - Pharmacy Repository·2022
2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors
ACS Medicinal Chemistry Letters·2021· 6 citedOpen Access
Micro-sized polyethylene particles decrease cell viability and increase mitochondrional superoxide production in human colorectal adenocarcinoma Caco-2 cells
Toxicology Letters·2021
Screening of SIRT6 inhibitors and activators: A novel activator has an impact on breast cancer cells
Biomedicine & Pharmacotherapy·2021· 17 citedOpen Access
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Frequent Co-authors

Antti Poso(22), Elina M. Jarho(16), Tiina Suuronen(11), Minna Rahnasto‐Rilla(9), Tarja Kokkola(8), Antero Salminen(8), Jukka Leppänen(6), Heikki S. Salo(6), Ruin Moaddel(5), Erik A. A. Wallén(5), Tero Huhtiniemi(5), Wim Vanden Berghe(4), Outi M. H. Salo‐Ahen(4), Marjo Huovinen(4), Paolo Mellini(4), Tomi Järvinen(4), Karen Heyninck(3), Chandra Sekhar Chirumamilla(3), Antonello Mai(3), Jonna Tyni(3)