Mariela C. Marazita

Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia — Argentina

Medicine · Health Sciences

13h-index762citations29works0.62yr avg
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Research Topics

Cancer-related Molecular Pathways(11), DNA Repair Mechanisms(8), Pluripotent Stem Cells Research(7), Microtubule and mitosis dynamics(6), Retinal Diseases and Treatments(5)

Publications29 total

Bridging Science and Care: 14 Years of Genetic and Biomarker Research in Neurodegenerative Diseases at an Argentine Memory Clinic
Alzheimer s & Dementia·2025Open Access
Clinical and functional evidence supporting the pathogenicity of the novel <i>PSEN1</i> p.R358P variant in early-onset Alzheimer's disease
Journal of Alzheimer s Disease·2025
Generation of human induced pluripotent stem cell lines from two down syndrome patients, including a down syndrome/Alzheimer’s disease case (FLENIi002-A) and a beta-amyloid-resistant case (FLENIi003-A)
Stem Cell Research·2025Open Access
Case report: A 50 year‐old Down syndrome man exhibiting no Alzheimer’s disease biomarker profile nor cognitive impairment. Experience from the Argentine Initiative for the Study of Down syndrome and Alzheimer’s
Alzheimer s & Dementia·2024Open Access
CDK5 Deficiency Does not Impair Neuronal Differentiation of Human Induced Pluripotent Stem Cells but Affects Neurite Outgrowth
Molecular Neurobiology·2024· 3 cited
Generation of a human induced pluripotent stem cell line (INEUi001-A) from an amyotrophic lateral sclerosis/frontotemporal dementia patient with a C9ORF72 G4C2 genotype of &lt;2 (GGGGCCG) and 10 repeats
Stem Cell Research·2023Open Access
Acute severe hypoxia induces apoptosis of human pluripotent stem cells by a HIF-1α and P53 independent mechanism
Scientific Reports·2022· 14 citedOpen Access
Perry disease in an Argentine family due to the DCTN1 p.G67D variant
Parkinsonism & Related Disorders·2022· 7 cited
Generation of a human induced pluripotent stem cell line from a familial Alzheimer's disease PSEN1 T119I patient
Stem Cell Research·2021· 5 citedOpen Access
Chemical hypoxia induces apoptosis of human pluripotent stem cells by a NOXA-mediated HIF-1α and HIF-2α independent mechanism
Scientific Reports·2020· 15 citedOpen Access
Ilex paraguariensis extracts and its polyphenols prevent oxidative damage and senescence of human retinal pigment epithelium cells
Journal of Functional Foods·2020· 23 citedOpen Access
Glucocorticoid and progesterone mechanisms in photoreceptor survival
Experimental Eye Research·2019· 8 citedOpen Access
Polyphenols in the prevention of oxidative stress-induced damage of ARPE-19 cells
Investigative Ophthalmology & Visual Science·2019Open Access
Steroids and photoreceptor survival in two models of retinal degeneration
2019
Palbociclib Effectively Halts Proliferation but Fails to Induce Senescence in Patient-Derived Glioma Stem Cells
Molecular Neurobiology·2019· 21 cited
Efecto protector de cafeico, clorogénico y yerba mate sobre las lesiones de la retina provocadas por daño oxidativo
Investigación Ciencia y Universidad·2018Open Access
Glucocorticoids and survival of retinal pigment epithelial cells (ARPE-19) in vitro
Investigative Ophthalmology & Visual Science·2017Open Access
Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
Redox Biology·2015· 197 citedOpen Access
CDK5-mediated phosphorylation of p19INK4d avoids DNA damage-induced neurodegeneration in mouse hippocampus and prevents loss of cognitive functions
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2014· 19 cited
Chromatin Relaxation-Mediated Induction of p19INK4d Increases the Ability of Cells to Repair Damaged DNA
PLoS ONE·2013· 13 citedOpen Access
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Frequent Co-authors

María Élida Scassa(11), Leonardo Romorini(11), Eduardo T. Cánepa(10), Gustavo Sevlever(9), Luciana Isaja(8), María F. Ogara(7), Ángela M. Suburo(7), Ezequiel Surace(7), Julieta M. Ceruti(6), Abel L. Carcagno(6), Melisa D. Marquioni‐Ramella(6), Silvina V. Sonzogni(6), Pablo Tate(6), Sofía Mucci(6), Pablo F. Sirkin(5), Tatiana Itzcovich(5), María Soledad Rodríguez-Varela(4), Ricardo Allegri(4), Omar P. Pignataro(3), Guillermo A. Videla-Richardson(3)