Karin S. Graffmo

Umeå University — Sweden

Medicine · Health Sciences

17h-index1.6kcitations24works0.02yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(24), Neurogenetic and Muscular Disorders Research(13), Parkinson's Disease Mechanisms and Treatments(5), Cholinesterase and Neurodegenerative Diseases(5), biodegradable polymer synthesis and properties(4)

Publications24 total

Widespread CNS pathology in amyotrophic lateral sclerosis homozygous for the D90A SOD1 mutation
Acta Neuropathologica·2022· 19 citedOpen Access
Misfolded SOD1 inclusions in patients with mutations in <i>C9orf72</i> and other ALS/FTD-associated genes
Journal of Neurology Neurosurgery & Psychiatry·2019· 88 citedOpen Access
Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping
Proceedings of the National Academy of Sciences·2015· 76 citedOpen Access
Extensive size variability of the GGGGCC expansion in C9orf72 in both neuronal and non-neuronal tissues in 18 patients with ALS or FTD
Human Molecular Genetics·2015· 117 citedOpen Access
Peripheral motor axons of SOD1G127X mutant mice are susceptible to activity-dependent degeneration
Neuroscience·2013· 10 cited
Composition of Soluble Misfolded Superoxide Dismutase-1 in Murine Models of Amyotrophic Lateral Sclerosis
NeuroMolecular Medicine·2012· 30 cited
Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis
Human Molecular Genetics·2012· 140 citedOpen Access
Nerve excitability changes related to axonal degeneration in amyotrophic lateral sclerosis: Insights from the transgenic SOD1G127X mouse model
Experimental Neurology·2011· 28 cited
Proteins That Bind to Misfolded Mutant Superoxide Dismutase-1 in Spinal Cords from Transgenic Amyotrophic Lateral Sclerosis (ALS) Model Mice
Journal of Biological Chemistry·2011· 46 citedOpen Access
Structure of soluble misfolded superoxide dismutase-1 in murine ALS models
2011
High expression of wild-type human superoxide dismutase-1 gives a model of sporadic ALS
2011
ALS patients with the SOD1 D90A mutation show both spinal cord and frontal cortical pathology
2011
Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase‐1 mutant mouse <i>in vivo</i>: evidence for increased persistent inward currents
Acta Physiologica·2010· 66 cited
Novel Antibodies Reveal Inclusions Containing Non-Native SOD1 in Sporadic ALS Patients
PLoS ONE·2010· 313 citedOpen Access
Superoxide dismutase‐1 and other proteins in inclusions from transgenic amyotrophic lateral sclerosis model mice
Journal of Neurochemistry·2010· 47 citedOpen Access
Superoxide dismutase in amyotrophic lateral sclerosis patients homozygous for the D90A mutation
Neurobiology of Disease·2009· 23 citedOpen Access
Changes in the Spinal Cord Proteome of an Amyotrophic Lateral Sclerosis Murine Model Determined by Differential In-gel Electrophoresis
Molecular & Cellular Proteomics·2009· 28 citedOpen Access
Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models
Proceedings of the National Academy of Sciences·2007· 168 citedOpen Access
SOD1-positive cytoplasmic and intranuclear inclusions are found in familial amyotrophic lateral sclerosis patients with the D90A superoxide dismutase 1 gene mutation
2007
Of mice and men : SOD1 associated human amyotrophic lateral sclerosis and transgenic mouse models
KTH Publication Database DiVA (KTH Royal Institute of Technology)·2007Open Access
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Frequent Co-authors

Stefan L. Marklund(21), Thomas Brännström(20), Peter M. Andersen(19), Karin Forsberg(9), P. Andreas Jonsson(8), Per Zetterström(7), Daniel Bergemalm(5), Mikael Oliveberg(3), Johan Bergh(3), Mihai Moldovan(3), Pär Jonsson(2), Susana Alvarez(2), Christian Krarup(2), Magnus Hultdin(1), Johan Jacobsson(1), Roland Rosquist(1), Mikael Lindberg(1), Heather Stewart(1), A. Birve(1), Angelica Nordin(1)