Thomas E. Spratt

Pennsylvania State University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index2.0kcitations87works1.42yr avg
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Research Topics

DNA Repair Mechanisms(40), DNA and Nucleic Acid Chemistry(29), Carcinogens and Genotoxicity Assessment(13), Cancer therapeutics and mechanisms(13), Synthesis and Biological Evaluation(12)

Publications87 total

Catalytic-Dependent Role of DNA Polymerase κ in Nucleotide Excision Repair
Chemical Research in Toxicology·2025
Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol
Cell Reports·2025· 3 citedOpen Access
Repair Mechanisms and Initiation in Carcinogenesis
Elsevier eBooks·2024
Activity of DNA polymerase κ across the genome in human fibroblasts
Proceedings of the National Academy of Sciences·2024· 3 citedOpen Access
Activity of DNA polymerase κ across the genome in human fibroblasts
2024· 1 citedOpen Access
Stephen S. Hecht Has Played a Major Role in Investigating Tobacco Carcinogenesis
Chemical Research in Toxicology·2023
Translesion DNA synthesis polymerase κ is essential to a carcinogen-induced nucleolar stress response
2022· 4 cited
Unique DNA Polymerase kappa Interactome Suggests Novel Cellular Functions
The FASEB Journal·2022
Zymo ChIP DNA Clean and Concentrator
ScholarSphere (Penn State Libraries)·2020Open Access
Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by <i>Escherichia coli</i> DNA Polymerase I
Chemical Research in Toxicology·2017Open Access
Mutagenic Replication of <i>N</i><sup>2</sup>-Deoxyguanosine Benzo[<i>a</i>]pyrene Adducts by <i>Escherichia coli</i> DNA Polymerase I and <i>Sulfolobus solfataricus</i> DNA Polymerase IV
Chemical Research in Toxicology·2017· 5 citedOpen Access
N<sup>2</sup>‐Substituted 2′‐Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ
Angewandte Chemie·2017· 2 cited
N<sup>2</sup>‐Substituted 2′‐Deoxyguanosine Triphosphate Derivatives as Selective Substrates for Human DNA Polymerase κ
Angewandte Chemie International Edition·2017· 22 citedOpen Access
Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells
Chemical Research in Toxicology·2017· 22 cited
DNA Polymerase ν Rapidly Bypasses <i>O</i><sup>6</sup>-Methyl-dG but Not <i>O</i><sup>6</sup>-[4-(3-Pyridyl)-4-oxobutyl-dG and <i>O</i><sup>2</sup>-Alkyl-dTs
Chemical Research in Toxicology·2016· 8 citedOpen Access
DNA Polymerases η and ζ Combine to Bypass <i>O</i><sup>2</sup>-[4-(3-Pyridyl)-4-oxobutyl]thymine, a DNA Adduct Formed from Tobacco Carcinogens
Chemical Research in Toxicology·2016· 13 citedOpen Access
Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O2-alkylthymidines in human cells
DNA repair·2015· 22 citedOpen Access
Human DNA Polymerase ν Catalyzes Correct and Incorrect DNA Synthesis with High Catalytic Efficiency
Journal of Biological Chemistry·2015· 10 citedOpen Access
<i>In Vitro</i> Epsilon RNA-Dependent Protein Priming Activity of Human Hepatitis B Virus Polymerase
Journal of Virology·2013Open Access
Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress
Cell Death and Disease·2013· 201 citedOpen Access
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Frequent Co-authors

Stephen S. Hecht(9), A. S. Prakasha Gowda(8), Lisa A. Peterson(6), Anthony E. Pegg(5), Shantu Amin(5), Philip Lazarus(4), Neil Trushin(3), Dongxiao Sun(3), Aviva S. Meyer(3), Steven G. Carmella(3), Robert D. Kuchta(3), Zucai Suo(3), Gang Chen(2), Ryan W. Dellinger(2), Sherri S. Schultz(2), Douglas E. Levy(2), William T. Wolfle(2), M. Todd Washington(2), Louise Prakash(2), Satya Prakash(2)