Timothy J. Ley

Washington University in St. Louis — United States

Medicine · Health Sciences

115h-index86.3kcitations539works1.12yr avg
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Research Topics

Acute Myeloid Leukemia Research(261), Cancer Genomics and Diagnostics(111), Epigenetics and DNA Methylation(57), Retinoids in leukemia and cellular processes(55), Protein Degradation and Inhibitors(39)

Publications506 total

Mechanisms of chemotherapy resistance driven by Mecom overexpression
Blood·2025Open Access
Missense mutations in the PWWP domain of DNMT3A can cause cytoplasmic mislocalization of DNMT3A in AML cells
Blood·2025
A prospective Study of whole genome sequencing for genomic profiling and risk determination in MDS
Blood·2025
Heterogeneity of immune escape mechanisms in de novo Acute Myeloid Leukemia
Blood·2025Open Access
Evaluation of Long-Read Genome Sequencing for Genomic Profiling of Myeloid Cancers
Journal of Molecular Diagnostics·2025Open Access
Overexpression of the signaling coordinator GAB2 can play an important role in acute myeloid leukemia progression
Journal of Clinical Investigation·2025· 2 citedOpen Access
Reduced <i>CBFB</i> Expression Causes Compensatory Upregulation of <i>RUNX1</i> Expression, Defining a Feedback Loop That May be Relevant for AML Pathogenesis
Blood·2024Open Access
Clearance of Leukemia Associated Mutations (LAMs) after Induction Therapy Is Associated with Favorable Outcomes in Intermediate Risk Acute Myeloid Leukemia: Interim Results of a Multicenter, Prospective Phase II Trial
Blood·2024· 1 cited
VISTA As a Mediator of Immune Suppression in AML Initiated By <i>DNMT3A</i> and <i>NPM1</i> mutations
Blood·2024
Recurrent Amplification of Chromosome 7 in Murine AML with <i>Dnmt3a</i>R878H and <i>Npm1</i>cA Mutations Identifies <i>Gab2</i> As a Possible Therapeutic Target in AML
Blood·2024Open Access
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells
Proceedings of the National Academy of Sciences·2024· 4 citedOpen Access
Molecular responses in decitabine- and decitabine/venetoclax-treated patients with acute myeloid leukemia and myelodysplastic syndromes
Haematologica·2024· 2 citedOpen Access
Abstract 5589: <i>CBFB::MYH11</i> expression activates <i>Trp53</i> in myeloid cells, which inhibits cell growth and sensitizes cells to cytarabine
Cancer Research·2024
Rapid and accurate remethylation of DNA in <i>Dnmt3a-</i> deficient hematopoietic cells with restoration of DNMT3A activity
Science Advances·2024· 6 citedOpen Access
Stabilizing the Proteomes of Acute Myeloid Leukemia Cells: Implications for Cancer Proteomics
Molecular & Cellular Proteomics·2024· 2 citedOpen Access
Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia–initiating CBFB::MYH11 oncofusion protein
Journal of Clinical Investigation·2023· 10 citedOpen Access
Supplementary Data for Stabilizing the Proteomes of Acute Myeloid Leukemia Cells: Implications for Cancer Proteomics
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Supplementary Data for Stabilizing the Proteomes of Acute Myeloid Leukemia Cells: Implications for Cancer Proteomics
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Mechanisms of PML::Rara and GATA2 Protein Interactions in Hematopoietic Cells
Blood·2023Open Access
Overexpression of the Signaling Integrator <i>Gab2</i> Accelerates AML Development in Mice with <i>Dnmt3a R878H</i>and <i>Npm1 cA</i> Mutations
Blood·2023Open Access
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Frequent Co-authors

Richard K. Wilson(26), Elaine R. Mardis(22), Li Ding(20), Robert S. Fulton(20), John F. DiPersio(20), Matthew J. Walter(19), Timothy A. Graubert(17), Christopher A. Miller(16), Peter Westervelt(16), Daniel C. Link(16), Michael D. McLellan(15), Sharon E. Heath(14), David E. Larson(13), John S. Welch(12), David J. Dooling(12), Jack Baty(11), Daniel C. Koboldt(10), Michael H. Tomasson(10), Joshua F. McMichael(9), Ken Chen(9)