J. Patrick Loria

Yale University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

42h-index6.8kcitations121works1.12yr avg
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Research Topics

Protein Structure and Dynamics(54), Enzyme Structure and Function(33), Protein Tyrosine Phosphatases(25), Advanced NMR Techniques and Applications(22), NMR spectroscopy and applications(17)

Publications121 total

Conformational Dynamics and Catalytic Backups in a Hyper-thermostable Engineered Archaeal Protein Tyrosine Phosphatase
JACS Au·2025Open Access
Distal Mutations Rewire Allosteric Networks to Control Substrate Specificity in PTP1B
Biochemistry·2025· 1 citedOpen Access
Conformational Dynamics and Catalytic Backups in a Hyper-Thermostable Engineered Archaeal Protein Tyrosine Phosphatase
2025Open Access
Unbiased clustering of residues undergoing synchronous motions in proteins using NMR spin relaxation data
Biophysical Chemistry·2025· 2 citedOpen Access
Conformational Dynamics and Catalytic Backups in a Hyper-Thermostable Engineered Archaeal Protein Tyrosine Phosphatase
SSRN Electronic Journal·2025Open Access
A salt bridge of the C‐terminal carboxyl group regulates <scp>PHPT1</scp> substrate affinity and catalytic activity
Protein Science·2024· 5 citedOpen Access
Unbiased Clustering of Residues Undergoing Synchronous Motions in Proteins Using Nmr Spin Relaxation Data
SSRN Electronic Journal·2024Open Access
Author Correction: Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase
Nature Communications·2023Open Access
Turning up the heat mimics allosteric signaling in imidazole-glycerol phosphate synthase
Nature Communications·2023· 16 citedOpen Access
CCDC 2115742: Experimental Crystal Structure Determination
The Cambridge Structural Database·2023Open Access
Unified total synthesis of the limonoid alkaloids: Strategies for the de novo synthesis of highly substituted pyridine scaffolds
Chem·2022· 12 citedOpen Access
Insights into the Importance of WPD-Loop Sequence for Activity and Structure in Protein Tyrosine Phosphatases
2022· 1 citedOpen Access
A simple method to determine changes in the affinity between HisF and HisH in the Imidazole Glycerol Phosphate Synthase heterodimer
PLoS ONE·2022Open Access
MptpA Kinetics Enhanced by Allosteric Control of an Active Conformation
Journal of Molecular Biology·2022· 10 citedOpen Access
Revealing the allosteric pathways of the protein-tyrosine phosphatase 1B: a combined mutagenesis-computational study
Biophysical Journal·2022· 1 cited
Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases
Chemical Science·2022· 42 citedOpen Access
Strategies for the De Novo Synthesis of Highly Substituted Pyridine Scaffolds: Unified Total Synthesis of the Limonoid Alkaloids
SSRN Electronic Journal·2022· 1 citedOpen Access
Correction to “Phosphorylation of a Human Microprotein Promotes Dissociation of Biomolecular Condensates”
Journal of the American Chemical Society·2021
Insights into the Importance of WPD-Loop Sequence for Activity and Structure in Protein Tyrosine Phosphatases
2021· 3 citedOpen Access
Insights into the Importance of WPD-Loop Sequence for Activity and Structure in Protein Tyrosine Phosphatases
2021· 2 citedOpen Access
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Frequent Co-authors

Arthur G. Palmer(8), Mark Rance(6), Víctor S. Batista(6), Ivan Rivalta(5), Gregory A. Manley(5), R. David Cole(5), Evgenii L. Kovrigin(5), George P. Lisi(5), Christopher D. Kroenke(4), J.M. Lipchock(4), George P. Lisi(3), Alvan C. Hengge(3), Michelle L. Gill(3), Rebecca B. Berlow(3), Eric D. Watt(3), James Kempf(3), Danica S. Cui(3), Heidi P. Hendrickson(2), Junming Ho(2), Scott A. Strobel(2)