Mark D. Lessard

Yale University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

21h-index3.0kcitations46works0.02yr avg
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Research Topics

Advanced Fluorescence Microscopy Techniques(12), Advanced Electron Microscopy Techniques and Applications(9), Lysosomal Storage Disorders Research(7), Hematopoietic Stem Cell Transplantation(5), Mitochondrial Function and Pathology(4)

Publications46 total

Pan-ASLM: a high-resolution and large field-of-view light sheet microscope for Expansion Microscopy
2025Open Access
An integrated platform for high-throughput nanoscopy
Nature Biotechnology·2023· 59 citedOpen Access
U2AF1 Splicing Factor Mutations Affect RNA Subcellular Compartmentalization in Myeloid Malignancies
Blood·2022· 1 cited
Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies
Molecular Cell·2022· 74 citedOpen Access
U2AF1 Mutations Enhance Stress Granule Response in Myeloid Malignancies
Blood·2021
Three-dimensional adaptive optical nanoscopy for thick specimen imaging at sub-50-nm resolution
Nature Methods·2021· 65 citedOpen Access
Multi-omics profiling of U2AF1 mutants dissects pathogenic mechanisms affecting RNA granules in myeloid malignancies
2021· 3 citedOpen Access
Implementation of a 4Pi-SMS super-resolution microscope
Nature Protocols·2020· 56 citedOpen Access
3D Adaptive Optical Nanoscopy for Thick Specimen Imaging at sub-50 nm Resolution
2020· 1 citedOpen Access
Nanoscale subcellular architecture revealed by multicolor three-dimensional salvaged fluorescence imaging
Nature Methods·2020· 138 citedOpen Access
Nanoscale subcellular architecture revealed by multicolor 3D salvaged fluorescence imaging
2019· 1 citedOpen Access
An Integrated Platform for High-Throughput Nanoscopy
2019· 19 citedOpen Access
Assessing photodamage in live-cell STED microscopy
Nature Methods·2018· 109 citedOpen Access
3D mapping of nanoscale crosslink heterogeneities in microgels
Materials Horizons·2018· 42 citedOpen Access
A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi
Molecular Biology of the Cell·2017· 73 citedOpen Access
Of Swords and Shields: The Role and Limits of Courts in the Enforcement of the Cape Town Convention’s Substantive Repossession Remedies
Cape Town Convention Journal·2017· 1 cited
Ultra-High Resolution 3D Imaging of Whole Cells
Cell·2016· 322 citedOpen Access
Hypoxic HepG2 cell adaptation decreases ATP synthase dimers and ATP production in inflated cristae by mitofilin down‐regulation concomitant to MICOS clustering
The FASEB Journal·2016· 46 cited
Distribution of mitochondrial DNA nucleoids inside the linear tubules vs. bulk parts of mitochondrial network as visualized by 4Pi microscopy
Journal of Bioenergetics and Biomembranes·2015· 14 cited
p63+Krt5+ distal airway stem cells are essential for lung regeneration
Nature·2014· 548 citedOpen Access
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Frequent Co-authors

Joerg Bewersdorf(23), Brian W. Soper(11), Jane E. Barker(11), Carole Vogler(7), Lena K. Schroeder(6), P. Kidd(6), Karla M. Neugebauer(6), Adam J.T. Schuldt(6), Yongdeng Zhang(5), Yuanbin Song(5), David Baddeley(5), Lydie Plecitá‐Hlavatá(5), Petr Ježek(5), Andrew E. S. Barentine(5), Beth Levy(5), Craig D. Jude(5), Edward S. Allgeyer(4), Félix Rivera-Molina(4), James E. Rothman(4), Martin J. Booth(4)