Lorenzo Pellegrini

Humanitas University — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.8kcitations19works1.02yr avg
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Research Topics

Cellular transport and secretion(12), Lipid Membrane Structure and Behavior(5), Genetic and Kidney Cyst Diseases(5), Erythrocyte Function and Pathophysiology(4), Botulinum Toxin and Related Neurological Disorders(3)

Publications19 total

Persistent primitive trigeminal artery in stroke: A review and clinical insights
AIMS neuroscience·2025· 1 citedOpen Access
Pre‐clinical evaluation of dual targeting of the GPCRs CaSR and V2R as therapeutic strategy for autosomal dominant polycystic kidney disease
The FASEB Journal·2021· 19 citedOpen Access
Use of Lixivaptan in a Patient with Autosomal Dominant Polycystic Kidney Disease (ADPKD) Who Previously Experienced Liver Toxicity with Tolvaptan
Journal of the American Society of Nephrology·2020
Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling
Pharmaceutical Research·2020· 29 citedOpen Access
Lixivaptan, a New Generation Diuretic, Counteracts Vasopressin-Induced Aquaporin-2 Trafficking and Function in Renal Collecting Duct Cells
International Journal of Molecular Sciences·2019· 20 citedOpen Access
Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model
American Journal of Nephrology·2019· 25 citedOpen Access
Kidney function in metabolic syndrome may be improved with Pycnogenol®.
PubMed·2010· 73 cited
Tuba, a Novel Protein Containing Bin/Amphiphysin/Rvs and Dbl Homology Domains, Links Dynamin to Regulation of the Actin Cytoskeleton
Journal of Biological Chemistry·2003· 185 citedOpen Access
Phosphatidylinositol 4-kinase type IIα is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles
Proceedings of the National Academy of Sciences·2003· 134 citedOpen Access
Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin
Nature·2002· 445 cited
PIP Kinase Iγ Is the Major PI(4,5)P2 Synthesizing Enzyme at the Synapse
Neuron·2001· 234 citedOpen Access
SNARE Complex Oligomerization by Synaphin/Complexin Is Essential for Synaptic Vesicle Exocytosis
Cell·2001· 153 citedOpen Access
The Epsins Define a Family of Proteins That Interact with Components of the Clathrin Coat and Contain a New Protein Module
Journal of Biological Chemistry·1999· 190 citedOpen Access
Protein interactions implicated in neurotransmitter release
Journal of Physiology-Paris·1998· 5 cited
Disruption of syntaxin-mediated protein interactions blocks neurotransmitter secretion
Proceedings of the National Academy of Sciences·1997· 101 citedOpen Access
Proteins Implicated in Neurotransmitter Release and Reuptake
1997
Protein-protein interactions in synaptic vesicle exocytosis
Biochemical Society Transactions·1996· 2 cited
Clostridial neurotoxins compromise the stability of a low energy SNARE complex mediating NSF activation of synaptic vesicle fusion.
The EMBO Journal·1995· 151 citedOpen Access
Fusion complex formation protects synaptobrevin against proteolysis by tetanus toxin light chain
FEBS Letters·1994· 53 citedOpen Access

Frequent Co-authors

Heinrich Betz(7), Vincent O’Connor(6), Pietro De Camilli(5), George J Augustine(4), Thomas Dresbach(4), Milton P. Charlton(4), Markus R. Wenk(3), Felix E. Schweizer(3), Gilbert Di Paolo(2), Gianluca Cestra(2), Sunghoe Chang(2), Jun Guo(2), Christian Heuss(2), Theo Schäfer(2), Xiaofang Wang(2), Vicente E. Torres(2), Annarita Di Mise(2), Giovanna Valenti(2), Oussama El Far(2), William M. DeBello(2)