Tadayoshi Karasawa

Jichi Medical University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

34h-index4.3kcitations85works7.32yr avg
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Research Topics

Inflammasome and immune disorders(47), Cholesterol and Lipid Metabolism(10), Pregnancy and preeclampsia studies(8), IL-33, ST2, and ILC Pathways(7), Heme Oxygenase-1 and Carbon Monoxide(6)

Publications84 total

Inflammasome-Independent Role of NLRP3 and ASC in Kidney Inflammation Triggered by Potassium Deficiency
Journal of the American Society of Nephrology·2025
Low Potassium Triggers Tubular Epithelial NLR Family Pyrin Domain-Containing 3/Apoptosis-Associated Speck-Like Protein-Containing a CARD–Driven Kidney Inflammation Independently of Inflammasomes
American Journal Of Pathology·2025· 1 cited
Colchicine as a Potential Anti-Inflammatory Strategy for Aortic Aneurysm
Circulation Journal·2025· 1 citedOpen Access
IL-33-primed NLRP3 inflammasome in basophils drives IL-1β production and initiates atopic dermatitis inflammation
Cell Death Discovery·2025· 3 citedOpen Access
IL-33-primed NLRP3 inflammasome in basophils drives IL-1β production and promotes atopic dermatitis inflammation
2025Open Access
AIM2 targeting of nuclear DNA leakage in dendritic cells exacerbates vasculitis in a murine model of Kawasaki disease
American Journal of Physiology-Heart and Circulatory Physiology·2025· 1 citedOpen Access
Inflammasome Activation and Neutrophil Extracellular Traps in Atherosclerosis
Journal of Atherosclerosis and Thrombosis·2025· 4 citedOpen Access
7-Dehydrocholesterol–Mediated Regulation of Ferroptosis in the Liver
Oleoscience·2025Open Access
Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
Nature Communications·2024· 58 citedOpen Access
Isoliquiritigenin inhibits <scp>NLRP3</scp> inflammasome activation with <scp>CAPS</scp> mutations by suppressing caspase‐1 activation and mutated <scp>NLRP3</scp> aggregation
Genes to Cells·2024· 9 citedOpen Access
Gasdermin D regulates soluble fms-like tyrosine kinase 1 release in macrophages
Reproductive Biology·2024· 3 cited
NLRP3 inflammasome-produced pro-inflammatory cytokines IL-1b and IL-18 are critical exacerbating factors of septic cardiomyopathy
European Heart Journal·2023· 3 citedOpen Access
Caspase-11 deficiency attenuates neutrophil recruitment into the atherosclerotic lesion in apolipoprotein E-deficient mice
Biochemical and Biophysical Research Communications·2023· 5 cited
NLRP3 inflammasome-driven IL-1β and IL-18 contribute to lipopolysaccharide-induced septic cardiomyopathy
Journal of Molecular and Cellular Cardiology·2023· 58 cited
A Myb enhancer-guided analysis of basophil and mast cell differentiation
Nature Communications·2022· 17 citedOpen Access
NLRP3 regulates inflammatory response in the uterus by seminal plasma and induces establishment of pregnancy in mice
Journal of Reproductive Immunology·2022
dsDNA-induced AIM2 pyroptosis halts aberrant inflammation during rhabdomyolysis-induced acute kidney injury
Cell Death and Differentiation·2022· 94 citedOpen Access
DHCR7 as a novel regulator of ferroptosis in hepatocytes
2022· 8 citedOpen Access
Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome
eLife·2022· 17 citedOpen Access
Author response: Cryo-sensitive aggregation triggers NLRP3 inflammasome assembly in cryopyrin-associated periodic syndrome
2022· 1 citedOpen Access
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Frequent Co-authors

Masafumi Takahashi(45), Hiroaki Kimura(27), Takanori Komada(20), Koumei Shirasuna(18), Sachiko Watanabe(16), Tadashi Kasahara(15), Ryo Kamata(14), Akira Kawashima(14), Naoya Yamada(13), Fumitake Usui(13), Yoshiko Mizushina(10), Motoi Kobayashi(9), Shun’ichiro Taniguchi(7), Yoshiyuki Inoue(7), Takashi Matsuzaka(6), Hitoshi Shimano(6), Naoya Yahagi(6), Naohiro Sata(6), Ai Sadatomo(6), Homare Ito(6)