David Patterson

Indiana University School of Medicine

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index14.9kcitations245works0.52yr avg
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Research Topics

Biochemical and Molecular Research(47), Genomic variations and chromosomal abnormalities(25), Genetics and Neurodevelopmental Disorders(17), HIV/AIDS drug development and treatment(16), Down syndrome and intellectual disability research(16)

Publications244 total

Difficult Patient Behaviors in the Hospital Setting: A Narrative Review
Journal of General Internal Medicine·2025· 1 citedOpen Access
1376 Whole transcriptome spatial profiling of the tumor microenvironment in FFPE, fresh frozen, and fixed frozen tissues
Regular and Young Investigator Award Abstracts·2024Open Access
1457 Visium HD enables spatially resolved, single-cell scale resolution mapping of FFPE human breast cancer tissue
Regular and Young Investigator Award Abstracts·2023· 31 citedOpen Access
Mitochondrial Targeting of Amyloid-β Protein Precursor Intracellular Domain Induces Hippocampal Cell Death via a Mechanism Distinct from Amyloid-β
Journal of Alzheimer s Disease·2022· 10 citedOpen Access
Aging with Down Syndrome—Where Are We Now and Where Are We Going?
Journal of Clinical Medicine·2021· 69 citedOpen Access
Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity
PLoS ONE·2021· 3 citedOpen Access
The Community Health and Social Medicine Incubator: a service-learning framework for medical student-led projects
Canadian Medical Education Journal·2021· 3 citedOpen Access
Reduced purine biosynthesis in humans after their divergence from Neandertals
eLife·2021· 24 citedOpen Access
Author response: Reduced purine biosynthesis in humans after their divergence from Neandertals
2021Open Access
Opportunities, barriers, and recommendations in Down syndrome research
Translational Science of Rare Diseases·2021· 96 citedOpen Access
AB42 and polyamines: Elucidating a potential mechanism of amyloid‐mediated apoptosis and aggregation
Alzheimer s & Dementia·2020· 1 cited
The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation
Molecular Genetics and Metabolism Reports·2020· 8 citedOpen Access
Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity
2020· 2 citedOpen Access
Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis
Nutrients·2020· 30 citedOpen Access
Reduced purine biosynthesis in humans after their divergence from Neandertals
2020· 5 citedOpen Access
The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation
2020· 1 citedOpen Access
The CRISPR-Cas9 crADSL HeLa transcriptome: A first step in establishing a model for ADSL deficiency and SAICAR accumulation
Molecular Genetics and Metabolism Reports·2019· 16 citedOpen Access
P2‐214: A NOVEL NEUROTOXIC ROLE OF THE APP INTRACELLULAR DOMAIN (AICD) AT THE MITOCHONDRIA, A DISTINCT MECHANISM FROM THAT OF Aβ
Alzheimer s & Dementia·2019
Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model
Neurobiology of Aging·2017· 8 citedOpen Access
Exosomal biomarkers in Down syndrome and Alzheimer's disease
Free Radical Biology and Medicine·2017· 74 citedOpen Access
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Frequent Co-authors

Iris Hart(4), David Nicholls(4), Ann‐Charlotte Granholm(4), John Bleskan(4), Margaret L. Van Keuren(3), Masahira Hattori(3), Yoshiyuki Sakaki(3), Stylianos E. Antonarakis(3), K. Gardiner(3), Kevin Clancy(3), Harry A. Drabkin(3), Michelle M. Le Beau(3), James F. Gusella(2), Paul C. Watkins(2), G.A.P. Bruns(2), David M. Kurnit(2), Rachael L. Neve(2), Asao Fujiyama(2), Tetsushi Yada(2), Atsushi Toyoda(2)