Theodore Cummins

Cincinnati Children's Hospital Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

68h-index16.1kcitations239works4.32yr avg
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Research Topics

Ion channel regulation and function(153), Neuroscience and Neuropharmacology Research(78), Pain Mechanisms and Treatments(70), Cardiac electrophysiology and arrhythmias(46), Neuroscience and Neural Engineering(23)

Publications234 total

Localization and duration dependent effects of pediatric refractory epilepsy on language function
Epilepsy & Behavior·2025Open Access
Contusive spinal cord injury causes Nav1.8 dysfunction to upregulate small sensory neuron excitability
The Journal of Physiology·2025Open Access
An approach to targeting Nav1.7 for pain sensations
Journal of Clinical Investigation·2025· 2 citedOpen Access
Müller glial Kir4.1 channel Dysfunction in <i>APOE4</i> -KI model of Alzheimer’s disease
2025· 2 citedOpen Access
Differential Regulation of Nav1.1 and SCN1A Disease Mutant Sodium Current Properties by Fibroblast Growth Factor Homologous Factors
Cells·2025Open Access
Molecular determinants of resurgent sodium currents mediated by Navβ4 peptide and A-type FHFs
Frontiers in Molecular Neuroscience·2024· 3 citedOpen Access
Induction of astrocyte reactivity promotes neurodegeneration in human pluripotent stem cell models
Stem Cell Reports·2024· 14 citedOpen Access
Peripherally targeted analgesia via AAV-mediated sensory neuron–specific inhibition of multiple pronociceptive sodium channels
Journal of Clinical Investigation·2024· 13 citedOpen Access
Decision letter: SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons
2022Open Access
CaMKII Inhibition Attenuates Distinct Gain-of-Function Effects Produced by Mutant Nav1.6 Channels and Reduces Neuronal Excitability
Cells·2022· 4 citedOpen Access
Astrocytes modulate neurodegenerative phenotypes associated with glaucoma in OPTN(E50K) human stem cell-derived retinal ganglion cells
Stem Cell Reports·2022· 35 citedOpen Access
Whole exome sequencing and co‐expression analysis identify an <i>SCN1A</i> variant that modifies pathogenicity in a family with genetic epilepsy and febrile seizures plus
Epilepsia·2022· 8 citedOpen Access
Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits NaV1.8 via Interactions With the DI Voltage Sensor and DII Pore Module
Frontiers in Pharmacology·2022· 4 citedOpen Access
Author response: A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels
2022Open Access
Neural Activity Correlates With Behavior Effects of Anti-Seizure Drugs Efficacy Using the Zebrafish Pentylenetetrazol Seizure Model
Frontiers in Pharmacology·2022· 18 citedOpen Access
A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels
2022Open Access
Peripherally targeted analgesia via AAV-mediated sensory neuron-specific inhibition of multiple pronociceptive sodium channels in rat
2021Open Access
Decision letter: NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats
2021Open Access
Identification and Characterization of Novel Proteins from Arizona Bark Scorpion Venom That Inhibit Nav1.8, a Voltage-Gated Sodium Channel Regulator of Pain Signaling
Toxins·2021· 5 citedOpen Access
Identification and characterization of novel proteins from Arizona bark scorpion venom that inhibit Nav1.8, a voltage-gated sodium channel regulator of pain signaling
2021· 1 citedOpen Access
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Frequent Co-authors

Stephen G. Waxman(30), Sulayman D. Dib‐Hajj(23), Joel A. Black(13), Muthukrishnan Renganathan(4), Raimund I. Herzog(4), Yucheng Xiao(4), Patrick L. Sheets(3), Anthony M. Rush(3), J.A. Black(3), Jenny Fjell(3), Lynda Tyrrell(3), James O. Jackson(3), Stephen G. Waxman(2), Masaki Tanaka(2), W. N. Hormuzdiar(2), Kaj Fried(2), Gabriel G. Haddad(2), Andrew D. Piekarz(2), Songping Liang(2), Nicole M. Ashpole(2)