Jan Eickhoff

Lead Discovery Center (Germany) — Germany

Medicine · Health Sciences

24h-index3.0kcitations68works2.22yr avg
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Research Topics

Cytomegalovirus and herpesvirus research(16), Cancer-related Molecular Pathways(10), Immune cells in cancer(7), Herpesvirus Infections and Treatments(6), Histone Deacetylase Inhibitors Research(6)

Publications68 total

Evaluating Triazole-Substituted Pyrrolopyrimidines as CSF1R Inhibitors
Molecules·2025Open Access
Design and Synthesis of Pyridine-Based Pyrrolo[2,3-d]pyrimidine Analogs as CSF1R Inhibitors: Molecular Hybridization and Scaffold Hopping Approach
Pharmaceuticals·2025Open Access
Development of a live cell assay for real-time monitoring the interactions between the Hippo pathway components 14-3-3 and TAZ
SLAS DISCOVERY·2024· 1 citedOpen Access
340 (PB328): Discovery of NODX-010, a novel, potent PARG inhibitor demonstrating robust in vivo efficacy and the potential for new clinical settings that benefit patients with tumours resistant to PARP inhibitors
European Journal of Cancer·2024
An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity
Pharmaceutics·2024· 10 citedOpen Access
Pyrrolopyrimidine based CSF1R inhibitors: Attempted departure from Flatland
European Journal of Medicinal Chemistry·2023· 6 citedOpen Access
ComplexEye: a multi-lens array microscope for high-throughput embedded immune cell migration analysis
Nature Communications·2023· 7 citedOpen Access
Combined Treatment with Host-Directed and Anticytomegaloviral Kinase Inhibitors: Mechanisms, Synergisms and Drug Resistance Barriers
Pharmaceutics·2023· 13 citedOpen Access
ComplexEye - a multi lens array microscope for High-Throughput embedded immune cell migration analysis
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
ComplexEye - a multi lens array microscope for High-Throughput embedded immune cell migration analysis
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Cytomegalovirus cyclin-dependent kinase ortholog vCDK/pUL97 undergoes regulatory interaction with human cyclin H and CDK7 to codetermine viral replication efficiency
Virus Research·2023· 10 citedOpen Access
Characterization of the Antibacterial Activity of Quinone-Based Compounds Originating from the Alnumycin Biosynthetic Gene Cluster of a Streptomyces Isolate
Antibiotics·2023· 6 citedOpen Access
ComplexEye - a multi lens array microscope for High-Throughput embedded immune cell migration analysis
2023Open Access
Synthesis and Development of Highly Selective Pyrrolo[2,3-<i>d</i>]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form
Journal of Medicinal Chemistry·2023· 13 citedOpen Access
IFNα primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization
Cell chemical biology·2023· 22 citedOpen Access
A highly selective purine-based inhibitor of CSF1R potently inhibits osteoclast differentiation
European Journal of Medicinal Chemistry·2023· 13 citedOpen Access
Assessment of Covalently Binding Warhead Compounds in the Validation of the Cytomegalovirus Nuclear Egress Complex as an Antiviral Target
Cells·2023· 9 citedOpen Access
Assessment of covalently binding warhead compounds in the validation of the cytomegalovirus nuclear egress complex as an antiviral target
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Assessment of covalently binding warhead compounds in the validation of the cytomegalovirus nuclear egress complex as an antiviral target
Zenodo (CERN European Organization for Nuclear Research)·2023Open Access
Data from Proteomic Characterization of the Angiogenesis Inhibitor SU6668 Reveals Multiple Impacts on Cellular Kinase Signaling
2023Open Access
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Frequent Co-authors

Bert Klebl(29), Axel Choidas(13), Matthias Baumann(12), Manfred Marschall(11), Anke Unger(10), Peter Habenberger(9), Carsten Schultz‐Fademrecht(9), Peter Nußbaumer(8), Susanne Kordes(5), Sascha Menninger(5), Arne Scholz(5), Sabrina Wagner(5), Matthew Cotten(5), Christina Wangen(5), Bård Helge Hoff(5), Eirik Sundby(5), Christian Ottmann(4), Ulrich Lücking(4), Philip Lienau(4), Gerhard Siemeister(4)