Anthony M. Treston

Emergent BioSolutions (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

28h-index3.1kcitations95works0.02yr avg
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Research Topics

Estrogen and related hormone effects(16), Neuropeptides and Animal Physiology(11), Neuroendocrine Tumor Research Advances(9), Lung Cancer Research Studies(9), Peptidase Inhibition and Analysis(9)

Publications95 total

Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum α-Glucosidase I with Anti-SARS-CoV-2 Activity
Journal of Medicinal Chemistry·2023· 22 citedOpen Access
Reproductive and developmental toxicology studies of iminosugar UV-4
Reproductive Toxicology·2022· 5 citedOpen Access
Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects
PLoS neglected tropical diseases·2022· 24 citedOpen Access
Identification of Endoplasmic Reticulum α-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design
Biochemistry·2022· 2 cited
Investigational New Drug Enabling Nonclinical Safety Assessment of the Iminosugar UV-4, a Broad-Spectrum Host-Targeted Antiviral Agent
International Journal of Toxicology·2022· 5 cited
Investigational New Drug Enabling Nonclinical Safety Pharmacology Assessment of the Iminosugar UV-4, a Broad-Spectrum Host-Targeted Antiviral Agent
International Journal of Toxicology·2022· 3 citedOpen Access
N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity
Journal of Medicinal Chemistry·2021· 65 cited
Iminosugars: A host-targeted approach to combat Flaviviridae infections
Antiviral Research·2020· 54 citedOpen Access
Targeting Endoplasmic Reticulum α-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections
Journal of Medicinal Chemistry·2020· 63 cited
GC-072, a Novel Therapeutic Candidate for Oral Treatment of Melioidosis and Infections Caused by Select Biothreat Pathogens
Antimicrobial Agents and Chemotherapy·2019· 7 citedOpen Access
Expression of Peptidyl-Glycine α-amidating Mono-Oxygenase (PAM) Enzymes in Morphological Abnormalities Adjecent to Pulmonary Tumors
Revista de medicina de la Universidad de Navarra·2017Open Access
Distribution of Peptidyl-Glycine a-Amidatyng
Revista de medicina de la Universidad de Navarra·2017Open Access
Assessment of the potential for host-targeted iminosugars UV-4 and UV-5 activity against filovirus infections in vitro and in vivo
Antiviral Research·2016· 35 cited
Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
Antiviral Research·2016· 67 citedOpen Access
A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate
Investigational New Drugs·2010· 87 citedOpen Access
A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer
Investigational New Drugs·2010· 48 cited
Structure elucidation by synthesis of four metabolites of the antitumor drug ENMD-1198 detected in human plasma samples
Tetrahedron·2009· 11 cited
Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs
Bioorganic & Medicinal Chemistry Letters·2009· 19 cited
Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure–activity relationships compared to 2-methoxyestradiol
Bioorganic & Medicinal Chemistry·2009· 19 cited
Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol
Bioorganic & Medicinal Chemistry Letters·2009· 14 cited
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Frequent Co-authors

James L. Mulshine(19), Frank Cuttitta(14), Ingalill Avis(11), Michele D. Vos(11), Alfredo Martı́nez(9), Jamshed H. Shah(7), Frank Scott(6), Kelly L. Warfield(6), Gregory E. Agoston(6), Philip G. Kasprzyk(5), Theresa LaVallee(5), Luis M. Montuenga(5), Kathryn Quinn(4), Carolyn Sidor(4), Lita S. Suwandi(4), Xiaoguo H. Zhan(4), Marti Jett(3), Edward J. Unsworth(3), Jun Zhou(3), J. L. Kiappes(3)