Andrew D. Burdick

Pfizer (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index1.3kcitations17works2.02yr avg
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Research Topics

RNA Interference and Gene Delivery(4), Peroxisome Proliferator-Activated Receptors(4), Virus-based gene therapy research(3), Cell death mechanisms and regulation(2), Drug Transport and Resistance Mechanisms(2)

Publications17 total

Nonclinical teratogenicity safety assessment of CRBN-engaging targeted protein degraders: Points to consider
Regulatory Toxicology and Pharmacology·2025· 2 cited
In vitro NIH3T3 mouse embryonic fibroblast cell model does not predict AAV2 or AAVdj-mediated cell transformation
Toxicology and Applied Pharmacology·2025· 2 cited
Microphysiological systems in early stage drug development: Perspectives on current applications and future impact
The Journal of Toxicological Sciences·2021· 38 citedOpen Access
Zucker Lean Rats With Hepatic Steatosis Recapitulate Asymptomatic Metabolic Syndrome and Exhibit Greater Sensitivity to Drug-Induced Liver Injury Compared With Standard Nonclinical Sprague-Dawley Rat Model
Toxicologic Pathology·2020· 4 cited
Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides
Nucleic Acids Research·2014· 161 citedOpen Access
Comparison of Hepatic Transcription Profiles of Locked Ribonucleic Acid Antisense Oligonucleotides: Evidence of Distinct Pathways Contributing to Non-target Mediated Toxicity in Mice
Toxicological Sciences·2013· 53 citedOpen Access
High‐Throughput Gene Silencing and mRNA Expression Analysis in Hepatocyte Sandwich Cultures
Current Protocols in Toxicology·2013· 2 cited
Safe, Long-term Hepatic Expression of Anti-HCV shRNA in a Nonhuman Primate Model
Molecular Therapy·2012· 58 citedOpen Access
Deregulation of tumor angiogenesis and blockade of tumor growth in PPARβ‐deficient mice
The EMBO Journal·2007· 98 citedOpen Access
Ligand activation of peroxisome proliferator-activated receptor-β/δ(PPARβ/δ) inhibits cell growth of human N/TERT-1 keratinocytes
Cellular Signalling·2007· 81 citedOpen Access
PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells
Carcinogenesis·2006· 42 citedOpen Access
The Toxicology of Ligands for Peroxisome Proliferator-Activated Receptors (PPAR)
Toxicological Sciences·2005· 255 citedOpen Access
The role of peroxisome proliferator-activated receptor-β/δ in epithelial cell growth and differentiation
Cellular Signalling·2005· 151 cited
Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species
Archives of Biochemistry and Biophysics·2005· 101 cited
Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells.
PubMed·2003· 188 cited
The aryl hydrocarbon receptor antagonist, 3′methoxy-4′nitroflavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line
Toxicology and Applied Pharmacology·2003· 35 cited
Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production.
PubMed·2001· 58 cited

Frequent Co-authors

Scott W. Burchiel(5), Jeffrey M. Peters(4), John W. Davis(4), Brett D. Hollingshead(4), Frank J. Gonzalez(3), Srinivasa R. Mantena(3), Laurence O. Whiteley(3), Fredine T. Lauer(3), Anna K. Kopec(3), Marjorie A. Peraza(2), Ke Jian Liu(2), Laurie G. Hudson(2), Honglian Shi(2), Michael Monske(2), James Warneke(2), Lori A. Reed(2), Kyle Hayes(2), James E. Finley(2), Holly E Marin(1), Simone Sciabola(1)