Swarnakumari Birudukota

Jubilant Life Sciences (India) — India

Medicine · Health Sciences

6h-index280citations13works0.02yr avg
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Research Topics

Sirtuins and Resveratrol in Medicine(5), Melanoma and MAPK Pathways(5), Biochemical and Molecular Research(4), PARP inhibition in cancer therapy(3), Protein Kinase Regulation and GTPase Signaling(2)

Publications13 total

Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
Scientific Reports·2022· 24 citedOpen Access
Novel, small molecule inhibitors of PD-1/PD-L1 pathway.
Journal of Clinical Oncology·2022· 8 cited
A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
Scientific Reports·2018· 96 citedOpen Access
Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with small molecule analog of Nicotinamide
2017· 1 cited
Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide
Biochemical and Biophysical Research Communications·2017· 17 cited
Crystal structure of mouse Nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl Nicotinamide (MNA)
2017
Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution
Biochemical and Biophysical Research Communications·2016· 25 cited
Crystal structure of PTK6 Kinase Domain complexed with Dasatinib
2016
Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Å resolution
Biochemical and Biophysical Research Communications·2016· 6 cited
Crystal structure of PTK6 Kinase domain with inhibitor
2015
Crystal structure of PTK6 kinase domain
2015
Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide
2013
Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors
ACS Medicinal Chemistry Letters·2013· 103 citedOpen Access

Frequent Co-authors

Ramachandraiah Gosu(11), Manish Thakur(9), Saravanan Kandan(6), Aimo Kannt(5), Sridharan Rajagopal(5), Rajiv Tyagi(5), Mahanandeesha S. Hallur(4), Reejuana Parveen(4), Sven Ruf(4), Saravanakumar Dhakshinamoorthy(4), S. Srinivasan(3), Rajendra Kristam(3), Christine Rudolph(3), Herman Schreuder(3), Niranjan Naranapura Anand(3), S. Swaminathan(3), Victor Gehling(2), Michael C. Hewitt(2), Rishi G. Vaswani(2), Alexandre Côté(2)