James K. Oeser

Vanderbilt University — United States

Medicine · Health Sciences

22h-index1.5kcitations49works1.52yr avg
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Research Topics

Pancreatic function and diabetes(36), Metabolism, Diabetes, and Cancer(32), Diabetes and associated disorders(12), Genetics and Neurodevelopmental Disorders(11), Glycogen Storage Diseases and Myoclonus(11)

Publications49 total

Multiple promoter and enhancer differences likely contribute to augmented G6PC2 expression in human versus mouse pancreatic islet alpha cells
Journal of Molecular Endocrinology·2024Open Access
Biochemical and metabolic characterization of a G6PC2 inhibitor
Biochimie·2024· 3 citedOpen Access
Identification of structural motifs critical for human G6PC2 function informed by sequence analysis and an AlphaFold2-predicted model
Bioscience Reports·2023· 4 citedOpen Access
G6PC1 and G6PC2 influence G6P flux but not HSD11B1 activity
Journal of Molecular Endocrinology·2023· 1 citedOpen Access
An Enhancer Within <i>Abcb11</i> Regulates <i>G6pc2</i> in C57BL/6 Mouse Pancreatic Islets
Diabetes·2023· 2 citedOpen Access
An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets
2023Open Access
An Enhancer Within Abcb11 Regulates G6pc2 in C57BL/6 Mouse Pancreatic Islets
2023Open Access
Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells
Journal of Biological Chemistry·2022· 25 citedOpen Access
Nonsynonymous single-nucleotide polymorphisms in the G6PC2 gene affect protein expression, enzyme activity, and fasting blood glucose
Journal of Biological Chemistry·2021· 18 citedOpen Access
Biophysical and functional properties of purified glucose-6-phosphatase catalytic subunit 1
Journal of Biological Chemistry·2021· 21 citedOpen Access
G6PC2 confers protection against hypoglycemia upon ketogenic diet feeding and prolonged fasting
Molecular Metabolism·2020· 11 citedOpen Access
Potential positive and negative consequences of ZnT8 inhibition
Journal of Endocrinology·2020· 14 citedOpen Access
Pancreatic islet beta cell-specific deletion of G6pc2 reduces fasting blood glucose
Journal of Molecular Endocrinology·2020· 36 citedOpen Access
Evidence that Evolution of the Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 Drives Variations in Pancreatic Islet Zinc Content in Multiple Species
Journal of Molecular Evolution·2019· 9 citedOpen Access
The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content
Journal of Molecular Evolution·2018· 6 cited
Exploring the Effect of G6PC2 Single Nucleotide Polymorphisms on Enzyme Activity and Human Health
ScholarWorks @ UTRGV (The University of Texas Rio Grande Valley)·2018Open Access
Effects of G6pc2 deletion on body weight and cholesterol in mice
Journal of Molecular Endocrinology·2017· 9 citedOpen Access
Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion
Endocrinology·2016· 36 citedOpen Access
G6PC2 Modulates the Effects of Dexamethasone on Fasting Blood Glucose and Glucose Tolerance
Endocrinology·2016· 21 citedOpen Access
Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression
PLoS ONE·2016· 12 citedOpen Access
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Frequent Co-authors

Richard M. O’Brien(48), Owen P. McGuinness(11), John C. Hutton(11), Christina A. Svitek(11), Yingda Wang(10), Lynley D. Pound(9), Cyrus Martin(9), Kristen Syring(9), Brian P. Flemming(8), Karin J. Bosma(7), Suparna A. Sarkar(6), Kayla A. Boortz(6), Emily M. Hawes(6), D.R. Powell(5), Lauri A. Hornbuckle(5), Philippe Froguel(5), Catherine E. Lee(4), David A. Jacobson(4), Joshua K. Goldman(4), Mohsin Rahim(4)