Rachel Grainger

Astex Pharmaceuticals

Engineering · Physical Sciences

10h-index883citations15works0.02yr avg
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Research Topics

Innovative Microfluidic and Catalytic Techniques Innovation(5), Computational Drug Discovery Methods(4), Catalytic C–H Functionalization Methods(4), Machine Learning in Materials Science(4), Radical Photochemical Reactions(2)

Publications15 total

Accelerated Chemical Reaction Optimization Using Multi-Task Learning
ACS Central Science·2023· 95 citedOpen Access
A Brief Introduction to Chemical Reaction Optimization
Chemical Reviews·2023· 370 citedOpen Access
Accelerated Chemical Reaction Optimization using Multi-Task Learning
2023· 7 citedOpen Access
Enabling synthesis in fragment-based drug discovery (FBDD): microscale high-throughput optimisation of the medicinal chemist's toolbox reactions
RSC Medicinal Chemistry·2023· 11 citedOpen Access
A Perspective on the Analytical Challenges Encountered in High-Throughput Experimentation
Organic Process Research & Development·2021· 54 cited
C–H functionalisation tolerant to polar groups could transform fragment-based drug discovery (FBDD)
Chemical Science·2021· 35 citedOpen Access
Transition metal-free cross-dehydrogenative arylation of unactivated benzylic C–H bonds
Chemical Communications·2020· 15 cited
Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines
Chemical Science·2018· 109 citedOpen Access
Photocatalytic Three-Component Umpolung Synthesis of 1,3-Diamines
Organic Letters·2018· 72 cited
CCDC 1857913: Experimental Crystal Structure Determination
The Cambridge Structural Database·2018Open Access
Decarboxylative transformations : synthetic applications and mechanistic investigations
2015
The <i>ortho</i>‐Substituent Effect on the Ag‐Catalysed Decarboxylation of Benzoic Acids
Chemistry - A European Journal·2014· 62 cited
Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids
Organic & Biomolecular Chemistry·2012· 53 cited
Category 6, Compounds with All-Carbon Functions
2009
1,3-Dienes
2009

Frequent Co-authors

Christopher N. Johnson(4), Gianni Chessari(4), Connor J. Taylor(3), Kobi Felton(3), Alexei A. Lapkin(3), Igor Larrosa(3), Daniel Wigh(2), Mohammed I. Jeraal(2), Thomas Rossolini(2), Jamie A. Leitch(2), Darren J. Dixon(2), Josep Cornellà(2), Stuart Whibley(2), V. H. Rawal(2), S. A. Kozmin(2), A. D. Abell(2), I. Bauer(2), E. M. Daly(2), C. R. Diène(2), Vincent Gandon(2)