Syu-ichi Hirai

Wakayama University — Japan

Biochemistry, Genetics and Molecular Biology · Life Sciences

31h-index5.3kcitations52works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(8), Melanoma and MAPK Pathways(6), Microtubule and mitosis dynamics(5), Neurogenesis and neuroplasticity mechanisms(5), Virus-based gene therapy research(4)

Publications52 total

The Map3k12 (Dlk)/JNK3 signaling pathway is required for pancreatic beta-cell proliferation during postnatal development
Cellular and Molecular Life Sciences·2020· 19 citedOpen Access
Sensory nerve supports epithelial stem cell function in healing of corneal epithelium in mice: the role of trigeminal nerve transient receptor potential vanilloid 4
Laboratory Investigation·2018· 50 citedOpen Access
A Role for DLK in Microtubule Reorganization to the Cell Periphery and in the Maintenance of Desmosomal and Tight Junction Integrity
Journal of Investigative Dermatology·2016· 20 cited
EphA4 Regulates the Balance between Self-Renewal and Differentiation of Radial Glial Cells and Intermediate Neuronal Precursors in Cooperation with FGF Signaling
PLoS ONE·2015· 9 citedOpen Access
Development of the External Genitalia and Their Sexual Dimorphic Regulation in Mice
Sexual Development·2014· 14 cited
Author Index Vol. 8, No. 5, 2014
Sexual Development·2014· 1 cited
The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain
BMC Cell Biology·2013· 11 citedOpen Access
Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death
Proceedings of the National Academy of Sciences·2013· 267 citedOpen Access
Axon Formation in Neocortical Neurons Depends on Stage-Specific Regulation of Microtubule Stability by the Dual Leucine Zipper Kinase–c-Jun N-Terminal Kinase Pathway
Journal of Neuroscience·2011· 78 citedOpen Access
Dominant-Negative Mutations in α-II Spectrin Cause West Syndrome with Severe Cerebral Hypomyelination, Spastic Quadriplegia, and Developmental Delay
The American Journal of Human Genetics·2010· 151 citedOpen Access
JNK phosphorylates Ser332 of doublecortin and regulates its function in neurite extension and neuronal migration
Neuroscience Research·2010· 4 cited
De novo mutations in the gene encoding STXBP1 (MUNC18-1) cause early infantile epileptic encephalopathy
Nature Genetics·2008· 539 cited
The c-Jun N-Terminal Kinase Activator Dual Leucine Zipper Kinase Regulates Axon Growth and Neuronal Migration in the Developing Cerebral Cortex
Journal of Neuroscience·2006· 145 citedOpen Access
Neonatal pancreatic cells redifferentiate into both neural and pancreatic lineages
Biochemical and Biophysical Research Communications·2006· 11 cited
Inactivation of aPKCλ results in the loss of adherens junctions in neuroepithelial cells without affecting neurogenesis in mouse neocortex
Development·2006· 7 cited
Developmental changes in the expression pattern of the JNK activator kinase MUK/DLK/ZPK and active JNK in the mouse cerebellum
Cell and Tissue Research·2006· 12 cited
Renal cell carcinoma- and pheochromocytoma-specific altered gene expression profiles in VHL mutant clones
Oncology Reports·2005· 11 cited
Expression of MUK/DLK/ZPK, an activator of the JNK pathway, in the nervous systems of the developing mouse embryo
Gene Expression Patterns·2005· 58 cited
A DNA vaccine containing inverted terminal repeats from adeno‐associated virus increases immunity to HIV
The Journal of Gene Medicine·2002· 23 cited
MAPK-upstream protein kinase (MUK) regulates the radial migration of immature neurons in telencephalon of mouse embryo
Development·2002· 84 cited
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Frequent Co-authors

Shigeo Ohno(22), Moshé Yaniv(10), Shin‐Ichi Osada(5), Masaya Baba(5), Keiko Mizuno(4), Rolf-Peter Ryseck(4), Atsushi Suzuki(3), R Bravo(3), Fatima Mechta‐Grigoriou(3), Heiwa Okuda(3), Yasuyuki Takaki(3), Taro Shuin(3), De Feng Cui(3), Yumi Banba(3), Jun Suenaga(3), Marilyn B. Renfree(3), Yoshihiko Ueda(2), Hirotomo Saitsu(2), Mitsuhiro Kato(2), Takeshi Mizuguchi(2)