Marcel P. Keller

Idorsia (Switzerland) — Switzerland

Medicine · Health Sciences

17h-index1.8kcitations40works3.32yr avg
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Research Topics

Systemic Lupus Erythematosus Research(6), Chemokine receptors and signaling(6), Immunotherapy and Immune Responses(5), Cytokine Signaling Pathways and Interactions(5), Hereditary Neurological Disorders(5)

Publications40 total

Pharmacodynamics of the S1P<sub>1</sub> receptor modulator cenerimod in a phase 2b randomised clinical trial in patients with moderate to severe SLE.
PubMed·2024· 1 cited
Discovery of the Clinical Candidate IDOR-1117-2520: A Potent and Selective Antagonist of CCR6 for Autoimmune Diseases
Journal of Medicinal Chemistry·2024· 9 citedOpen Access
Quantification of increased biologically active CXCL12α plasma concentrations after ACKR3 antagonist treatment in humans
Clinical and Translational Science·2024Open Access
Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies
Journal of Medicinal Chemistry·2023· 14 citedOpen Access
Vorschau: Chem. Ing. Tech. 12/2022
Chemie Ingenieur Technik·2022Open Access
CCDC 2169955: Experimental Crystal Structure Determination
The Cambridge Structural Database·2022Open Access
Design, Synthesis, and Pharmacological Evaluation of Benzimidazolo-thiazoles as Potent CXCR3 Antagonists with Therapeutic Potential in Autoimmune Diseases: Discovery of ACT-672125
Journal of Medicinal Chemistry·2022· 6 citedOpen Access
Discovery and <i>In Vivo</i> Evaluation of ACT-660602: A Potent and Selective Antagonist of the Chemokine Receptor CXCR3 for Autoimmune Diseases
Journal of Medicinal Chemistry·2022· 6 citedOpen Access
In Vitro Characterization of Sphingosine 1-Phosphate Receptor 1 (S1P1) Expression and Mediated Migration of Primary Human T and B Cells in the Context of Cenerimod, a Novel, Selective S1P1 Receptor Modulator
International Journal of Molecular Sciences·2022· 7 citedOpen Access
AB0024 IN VITRO CHARACTERIZATION OF CENERIMOD, A POTENT AND SELECTIVE SPHINGOSINE 1-PHOSPHATE RECEPTOR 1 (S1P1) MODULATOR IN PREVENTING MIGRATION OF NON-ACTIVATED AND ACTIVATED PRIMARY HUMAN B CELLS IN THE PRESENCE OR ABSENCE OF GLUCOCORTICOIDS
Annals of the Rheumatic Diseases·2021
Preclinical to clinical translation of cenerimod, a novel S1P<sub>1</sub> receptor modulator, in systemic lupus erythematosus
RMD Open·2020· 20 citedOpen Access
Immunoaffinity Targeted Mass Spectrometry Analysis of Human Plasma Samples Reveals an Imbalance of Active and Inactive CXCL10 in Primary Sjögren’s Syndrome Disease Patients
Journal of Proteome Research·2020· 12 cited
SAT0165 PRECLINICAL AND CLINICAL CHARACTERIZATION OF CENERIMOD, A POTENT, SELECTIVE, AND ORALLY ACTIVE SPHINGOSINE-1-PHOSPHATE RECEPTOR 1 MODULATOR IN SLE
Annals of the Rheumatic Diseases·2020· 1 citedOpen Access
THU0008 DEVELOPMENT OF A NOVEL TRANSLATIONAL IN SILICO INDICATION DISCOVERY FRAMEWORK: EXEMPLIFIED BY THE CLINICAL COMPOUND CENERIMOD
Annals of the Rheumatic Diseases·2020Open Access
P138 Preclinical and clinical characterization of cenerimod, a potent, selective, and orally active sphingosine-1-phosphate receptor 1 modulator in SLE
Poster presentations·2020· 1 citedOpen Access
Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells
Nature Immunology·2016· 183 citedOpen Access
A subpopulation of CD103<sup>pos</sup>ICOS<sup>pos</sup> Treg cells occurs at high frequency in lymphopenic mice and represents a lymph node specific differentiation stage
European Journal of Immunology·2015· 8 citedOpen Access
Abstract 3081: Loss of Shoca-2 expression in colorectal cancer correlates with metastasis as Shoca-2 represses EGF-regulated STAT3 activation via recruitment of PP1beta
Cancer Research·2010
Stabilized β-Catenin in Thymic Epithelial Cells Blocks Thymus Development and Function
The Journal of Immunology·2009· 80 citedOpen Access
Maintenance of a normal thymic microenvironment and T-cell homeostasis require Smad4-mediated signaling in thymic epithelial cells
Blood·2008· 18 citedOpen Access
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Frequent Co-authors

Georg A. Holländer(11), Daniel S. Strasser(8), Saulius Žuklys(7), Mark Murphy(7), Lukas T. Jeker(5), Thomas Barthlott(5), Phillip F. Chance(5), Marianne M. Martinic(5), Emmanuel A. Meyer(5), Eva Caroff(5), Paulina Kulig(5), Luca Piali(4), Werner Krenger(4), Mathias Hauri‐Hohl(4), Gabin Pierlot(4), Päivi Äänismaa(4), Sylvie Froidevaux(4), Hervé Farine(4), Jason Gill(3), Katrin Hafen(3)