Luigi Naldini

Vita-Salute San Raffaele University — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

120h-index62.6kcitations569works7.62yr avg
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Research Topics

Virus-based gene therapy research(257), CRISPR and Genetic Engineering(163), RNA Interference and Gene Delivery(126), CAR-T cell therapy research(120), Immune cells in cancer(50)

Publications568 total

Lentiviral hematopoietic stem and progenitor cell gene therapy with Etuvetidigene autotemcel for the treatment of Wiskott-Aldrich Syndrome
Blood·2025
1007 Bridging species barriers: a humanized model for macrophage-directed <i>in vivo</i> gene therapy in liver metastases
Regular and Young Investigator Award Abstracts·2025Open Access
1000  <i>In vivo</i> macrophage engineering to deliver new immune-activating molecules to liver metastases
Regular and Young Investigator Award Abstracts·2025Open Access
Non-neurological, non-skeletal outcomes after hematopoietic stem and progenitor cell-gene therapy (OTL-203) for Hurler syndrome
Molecular Therapy·2025· 2 citedOpen Access
WITHDRAWN: 2683eTiP TEM-GU: A phase I/II clinical study of a genetically-modified Tie-2 expressing monocytes in patients with metastatic renal cell carcinoma
Annals of Oncology·2025
Tumor-targeted cytokine delivery by engineered myeloid cells unlocks CAR T cell efficacy and endogenous T cell responses in glioblastoma
Molecular Therapy·2025Open Access
A cross-talk established by tumor-targeted cytokines rescues CAR T cell activity and engages host T cells against glioblastoma in mice
Science Translational Medicine·2025· 4 cited
Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cells
Cell Reports Medicine·2025· 5 citedOpen Access
In vivo haemopoietic stem cell gene therapy enabled by postnatal trafficking
Nature·2025· 9 citedOpen Access
OS-009 Tumor size-dependent endothelial switch modulates CD8+ T cell immune surveillance in liver cancer
Journal of Hepatology·2025
Abstract LB029: TIGIT deletion rescues the antitumor activity of low avidity T cells by increasing TCR signal strength
Cancer Research·2025
Long-Term Effects of Atidarsagene Autotemcel for Metachromatic Leukodystrophy
New England Journal of Medicine·2025· 14 cited
Reprogramming liver metastasis-associated macrophages toward an anti-tumoral phenotype through enforced miR-342 expression
Cell Reports·2025· 3 citedOpen Access
Metformin reduces the competitive advantage of Dnmt3aR878H HSPCs
Nature·2025· 33 cited
Response to: Safety and efficacy considerations of HSC-based gene therapy for RAG1-deficient SCID
Molecular Therapy·2025
In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation
Nature Communications·2025· 9 citedOpen Access
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome
Nature Medicine·2025· 29 citedOpen Access
Challenges and solutions to the sustainability of gene and cell therapies
Nature Reviews Genetics·2025· 6 cited
Identification of hepatocyte-primed cholangiocytes in the homeostatic liver by in vivo lentiviral gene transfer to mice and non-human primates
Cell Reports·2025· 3 citedOpen Access
Balancing efficacy and safety in lentiviral vector-mediated hematopoietic stem cell gene therapy
Molecular Therapy·2024· 8 citedOpen Access
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Frequent Co-authors

Eugenio Montini(7), Pietro Genovese(7), Didier Trono(6), Michele De Palma(6), Mary Anna Venneri(6), Clelia Di Serio(6), Angelo Lombardo(6), Philip D. Gregory(6), Michael C. Holmes(6), Maurilio Ponzoni(6), Chiara Bonini(6), Andrea Calabria(5), Manfred Schmidt(5), Christof von Kalle(5), Fabio Ciceri(5), Elisa Vigna(5), Bernhard Gentner(5), Giovanni Gaudino(4), Paolo M. Comoglio(4), Lucia Sergi Sergi(4)