C. James Chou

NXP (Netherlands) — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index4.3kcitations115works2.92yr avg
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Research Topics

Histone Deacetylase Inhibitors Research(45), Protein Degradation and Inhibitors(24), Schizophrenia research and treatment(20), Peptidase Inhibition and Analysis(20), Bipolar Disorder and Treatment(13)

Publications115 total

Dielectric Dry Etch Patterning Used In Single Gate EUV Spin Qubit Device
2025
Automotive Application-driven Vibration Test Approach: Bridging the Gap between Module and Board Level Reliability Test Methods
2025
Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD
Advanced Science·2025· 3 citedOpen Access
Methodology to Obtain the Operation Reaction Loads in Automotive Fuel Filler Door
SAE technical papers on CD-ROM/SAE technical paper series·2024
Targeted multiplex proteomics for the development and validation of biomarkers in primary aldosteronism subtyping
European Journal of Endocrinology·2024· 6 citedOpen Access
418P Concordance of PI3K-AKT pathway alterations between tumor and ctDNA in metastatic breast cancer
Annals of Oncology·2024· 2 citedOpen Access
Novel Mitochondrial Protective Agent for Parkinson’s Disease Targeting the PINK1/LRRK2 Axis
Neurotherapeutics·2024Open Access
Understanding board level vibrations in automotive electronic modules
Microelectronics Reliability·2024· 6 cited
LP340, a novel histone deacetylase inhibitor, decreases liver injury and fibrosis in mice: role of oxidative stress and microRNA-23a
Frontiers in Pharmacology·2024· 4 citedOpen Access
HDAC/NAMPT dual inhibitors overcome initial drug-resistance in p53-null leukemia cells
European Journal of Medicinal Chemistry·2024· 8 citedOpen Access
Su1525 HISTONE DEACETYLASE-11 (HDAC11) INHIBITION AS A NOVEL THERAPEUTIC APPROACH FOR NON-ALCOHOLIC STEATOHEPATITIS (NASH)
Gastroenterology·2023
LP342, a novel histone deacetylase inhibitor, decreases nitro-oxidative stress, mitochondrial dysfunction and hepatic ischaemia/reperfusion injury in mice
RPS Pharmacy and Pharmacology Reports·2023· 8 citedOpen Access
First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation
Journal of Medicinal Chemistry·2022· 56 citedOpen Access
Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms
Gastroenterology·2022· 110 citedOpen Access
Comparison of three zinc binding groups for HDAC inhibitors – A potency, selectivity and enzymatic kinetics study
Bioorganic & Medicinal Chemistry Letters·2022· 25 citedOpen Access
Potent Hydrazide-Based HDAC Inhibitors with a Superior Pharmacokinetic Profile for Efficient Treatment of Acute Myeloid Leukemia In Vivo
Journal of Medicinal Chemistry·2021· 56 citedOpen Access
Development of selective HDAC6 inhibitors with in vitro and in vivo anti-multiple myeloma activity
Bioorganic Chemistry·2021· 23 cited
Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects <i>In Vitro</i> and Neuroprotective Effects in a Pharmacological Alzheimer’s Disease Mouse Model
Journal of Medicinal Chemistry·2021· 57 citedOpen Access
Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC
Molecules·2020· 22 citedOpen Access
Synthesis and biological study of class I selective HDAC inhibitors with NO releasing activity
Bioorganic Chemistry·2020· 10 cited
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Frequent Co-authors

Xiaoyang Li(15), Elizabeth S. Inks(11), Yingjie Zhang(9), Wenfang Xu(7), Joel Gottesfeld(6), Jesse J. McClure(5), Mark R. Serper(5), Robert Cancro(5), Jie Zang(4), Yuri K. Peterson(4), Benjamin J. Josey(4), Yuqi Jiang(4), Donald R. Menick(4), Pál Czobor(3), Elisabetta Soragni(3), James R. Rusche(3), Xuewu Liang(3), Cheng Zhang(3), Jiaying Li(3), Danielle Richarme(3)