Manolis Pasparakis

University of Cologne — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

97h-index44.2kcitations302works5.82yr avg
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Research Topics

NF-κB Signaling Pathways(90), Immune Response and Inflammation(81), interferon and immune responses(63), Cell death mechanisms and regulation(55), Inflammasome and immune disorders(27)

Publications299 total

Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis
Cell Death and Disease·2026Open Access
DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
Science·2026Open Access
Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression
Nature Communications·2025· 1 citedOpen Access
Aging-Associated Microbiota Drives Treg Dysfunction via TNF Signaling
2025Open Access
Corrigendum to Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis
Journal of Clinical Investigation·2025Open Access
492 Apoptosis, the silent cell death - Challenging the dogma
Journal of Investigative Dermatology·2025
Author Correction: TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
Nature·2025Open Access
Cell-death networks
Molecular Cell·2025
RIPK1 autophosphorylation at S161 mediates cell death and inflammation
The Journal of Experimental Medicine·2025· 2 citedOpen Access
The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity
2025Open Access
Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier
Immunity·2025· 4 citedOpen Access
Aging-Associated Microbiota Drives Treg Dysfunction via TNF Signaling
2025Open Access
Low Caspase 8 Expression Promotes Neuronal Progenitor Mimicry and Small Cell Lung Cancer Metastasis
Journal of Thoracic Oncology·2025
Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis
2025Open Access
Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway
Cancer Cell·2025· 1 citedOpen Access
Dessicating stress triggers and exacerbates experimental ocular Graft-versus-host-disease
The Ocular Surface·2025Open Access
MLKL activity requires a splicing-regulated, druggable intramolecular interaction
Molecular Cell·2025· 7 citedOpen Access
RANK drives structured intestinal epithelial expansion during pregnancy
Nature·2024· 14 citedOpen Access
526 Macrophage cell death instructs fibroblast-repair functions in skin wound healing
Journal of Investigative Dermatology·2024
Desiccation Stress Triggers and Exacerbates Experimental Ocular Graft-Versus-Host-Disease
Blood·2024
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Frequent Co-authors

George Kollias(9), Geert Loo(9), Laurens Wachsmuth(6), Maria Ermolaeva(5), Snehlata Kumari(5), Apostolos Polykratis(5), Marc Schmidt‐Supprian(5), Klaus Rajewsky(5), Robin Schwarzer(4), Ingo Haase(4), Michelle A. Kelliher(4), Chun Kim(4), Matija Zelic(4), Patrick-Simon Welz(3), Arianna Nenci(3), Andy Wullaert(3), Katerina Vlantis(3), Vangelis Kondylis(3), Juan Lin(3), Marion J. Gijbels(3)