Denis J. Schrier

Medicine · Health Sciences

32h-index4.5kcitations85works2.02yr avg
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Research Topics

Inflammatory mediators and NSAID effects(17), Synthesis and biological activity(13), Immune Response and Inflammation(10), Cell Adhesion Molecules Research(10), Synthesis and Reactions of Organic Compounds(10)

Publications84 total

Recombinant ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) decreases vascular calcification and prevents osteomalacia in a rat model of chronic kidney disease
JBMR Plus·2025· 2 citedOpen Access
Author response for "INZ ‐701 prevents ectopic tissue calcification and restores bone architecture and growth in ENPP1 deficient mice"
2021Open Access
Author response for "INZ ‐701 prevents ectopic tissue calcification and restores bone architecture and growth in ENPP1 deficient mice"
2021Open Access
INZ-701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth in ENPP1-Deficient Mice
Journal of Bone and Mineral Research·2020· 40 citedOpen Access
Integrated toxicological and safety pharmacology evaluation of a novel monoclonal antibody therapy for ocular disease in the cynomolgus monkey
Journal of Pharmacological and Toxicological Methods·2014
Identificazione dei progenitori inducibili degli adipociti bruni residenti nel muscolo scheletrico e nel tessuto adiposo bianco
L Endocrinologo·2011
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
Proceedings of the National Academy of Sciences·2010· 449 citedOpen Access
82. Posterolateral Intertransverse Lumbar Fusion in Nonhuman Primates Using OP-1 Putty: Effect of Dose Concentration on Fusion Rate
The Spine Journal·2008· 1 cited
Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: Potential proinflammatory mechanisms
Arthritis & Rheumatism·2007· 99 citedOpen Access
Oral treatment with PD‐0200347, an α<sub>2</sub>δ ligand, reduces the development of experimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes
Arthritis & Rheumatism·2005· 60 cited
Oral treatment with PD-0200347, an α(2)δ ligand, reduces the development of experimental osteoarthritis by inhibiting the chondrocytes metalloproteases and inducible nitric oxide synthase gene expression and synthesis
Arthritis Research·2004Open Access
Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis
Osteoarthritis and Cartilage·2003· 497 citedOpen Access
In vivo selective inhibition of mitogen‐activated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes
Arthritis & Rheumatism·2003· 135 cited
New strategies for the in vivo regulation of metalloprotease gene expression in osteoarthritis chondrocytes by inflammatory mediators
Arthritis Research·2003Open Access
Ribozymes as Tools for Therapeutic Target Validation in Arthritis
The Journal of Immunology·2000· 16 citedOpen Access
Cell adhesion molecules and leukocyte trafficking
Birkhäuser Basel eBooks·2000
Effects of the phosphodiesterase inhibitor rolipram on streptococcal cell wall-induced arthritis in rats
International Journal of Immunopharmacology·1999· 24 cited
Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-<i>tert</i>-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 2. 1,3,4- and 1,2,4-Thiadiazole Series
Journal of Medicinal Chemistry·1999· 120 cited
Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Substituted Di-<i>tert</i>-butylphenols as a Novel Class of Potent, Selective, and Orally Active Cyclooxygenase-2 Inhibitors. 1. Thiazolone and Oxazolone Series
Journal of Medicinal Chemistry·1999· 130 citedOpen Access
Effects of Novel Anti-Inflammatory Compounds on Healing of Acetic Acid-Induced Gastric Ulcer in Rats
Journal of Pharmacology and Experimental Therapeutics·1998· 30 cited
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Frequent Co-authors

Richard D. Dyer(10), Craig M. Flory(10), Mark E. Lesch(9), David T. Connor(7), Peter A. Ward(7), Sem H. Phan(6), Richard B. Gilbertsen(6), Clifford D. Wright(5), Paul C. Unangst(5), Jagadish C. Sircar(5), Ralph C. Schimmer(5), Vernon L. Moore(5), Catherine R. Kostlan(4), Roderick J. Sorenson(4), H. P. Friedl(4), Peer B. Jacobson(4), Elizabeth M. Allen(4), Dirk A. Bornemeier(3), D. T. CONNOR(3), Yuntao Song(3)